Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China
© 2021. Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature..
Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in coronavirus disease 2019 (COVID-19) patients have been reported. However, the clinical outcome and pathogenesis remain unclear. In this study, we recruited 43 laboratory-confirmed COVID-19 patients. We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients (P<0.05). The average viral shedding time in severe/critical patients was more than 50 days, and up to 100 days in some patients, after symptom onset. However, chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive, but specific antibodies appeared. Furthermore, the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred (P<0.01 and FDR<0.01) and increased when G227A occurred (P<0.05 and FDR<0.05). High IL1R1, IL1R2, and TNFRSF21 expression in the host positively correlated with viral shedding time (P<0.05 and false discovery rate <0.05). Prolonged viral RNA shedding often occurs but may not increase disease damage. Prolonged viral RNA shedding is associated with viral mutations and host factors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:64 |
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| Enthalten in: |
Science China. Life sciences - 64(2021), 12 vom: 04. Dez., Seite 2129-2143 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Zhengtu [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies, Neutralizing |
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| Anmerkungen: |
Date Completed 07.01.2022 Date Revised 07.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11427-020-1921-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM324980515 |
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| 245 | 1 | 0 | |a Longitudinal virological changes and underlying pathogenesis in hospitalized COVID-19 patients in Guangzhou, China |
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| 520 | |a Prolonged viral RNA shedding and recurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in coronavirus disease 2019 (COVID-19) patients have been reported. However, the clinical outcome and pathogenesis remain unclear. In this study, we recruited 43 laboratory-confirmed COVID-19 patients. We found that prolonged viral RNA shedding or recurrence mainly occurred in severe/critical patients (P<0.05). The average viral shedding time in severe/critical patients was more than 50 days, and up to 100 days in some patients, after symptom onset. However, chest computed tomography gradually improved and complete absorption occurred when SARS-CoV-2 RT-PCR was still positive, but specific antibodies appeared. Furthermore, the viral shedding time significantly decreased when the A1,430G or C12,473T mutation occurred (P<0.01 and FDR<0.01) and increased when G227A occurred (P<0.05 and FDR<0.05). High IL1R1, IL1R2, and TNFRSF21 expression in the host positively correlated with viral shedding time (P<0.05 and false discovery rate <0.05). Prolonged viral RNA shedding often occurs but may not increase disease damage. Prolonged viral RNA shedding is associated with viral mutations and host factors | ||
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| 700 | 1 | |a Sun, Ruilin |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Shaoqiang |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Lingdan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhan, Yangqing |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Mingzhou |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Jiasheng |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yanqun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Airu |e verfasserin |4 aut | |
| 700 | 1 | |a Gu, Guoping |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Le |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Shuaicheng |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Tingting |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Zhaoming |e verfasserin |4 aut | |
| 700 | 1 | |a Jian, Wenhua |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Qian |e verfasserin |4 aut | |
| 700 | 1 | |a Su, Xiaofen |e verfasserin |4 aut | |
| 700 | 1 | |a Gu, Weili |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Liyan |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Jincun |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Wenju |e verfasserin |4 aut | |
| 700 | 1 | |a Zheng, Jinping |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Shiyue |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, Nanshan |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Feng |e verfasserin |4 aut | |
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