Human cytomegalovirus and Epstein-Barr virus infections in breast cancer : A molecular study on Iranian women
BACKGROUND AND OBJECTIVES: The role of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) infections in breast cancer pathology is not well understood. Our study aimed to investigate the association of HCMV and EBV infections with breast cancer and distinguish the types of positive EBV and LMP-1 samples in Iranian patients.
METHODS: Seventy-two formalin-fixed paraffin-embedded (FFPE) breast cancer tissues were analyzed between December 2014 and April 2016. Samples were analyzed for HCMV and EBV using nested-PCR and conventional PCR assays, respectively. Statistical analysis was performed using SPSS software version 18.
RESULTS: Overall, HCMV and EBV genomes were detected in 6.9% and 16.7% of FFPE breast cancer tissues, respectively. Clinical factors were not statistically associated with the presence of HCMV and EBV.
CONCLUSION: In this study, we reported EBV and LMP-1 typing in breast carcinoma cases for the first time in Iran. Our findings indicate that HCMV and EBV infections are not associated with the development of breast cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Breast disease - 40(2021), 4 vom: 15., Seite 227-233 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ghaffari, Hadi [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 10.01.2022 Date Revised 10.01.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.3233/BD-201019 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM324881533 |
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| 245 | 1 | 0 | |a Human cytomegalovirus and Epstein-Barr virus infections in breast cancer |b A molecular study on Iranian women |
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| 500 | |a Date Completed 10.01.2022 | ||
| 500 | |a Date Revised 10.01.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND AND OBJECTIVES: The role of human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV) infections in breast cancer pathology is not well understood. Our study aimed to investigate the association of HCMV and EBV infections with breast cancer and distinguish the types of positive EBV and LMP-1 samples in Iranian patients | ||
| 520 | |a METHODS: Seventy-two formalin-fixed paraffin-embedded (FFPE) breast cancer tissues were analyzed between December 2014 and April 2016. Samples were analyzed for HCMV and EBV using nested-PCR and conventional PCR assays, respectively. Statistical analysis was performed using SPSS software version 18 | ||
| 520 | |a RESULTS: Overall, HCMV and EBV genomes were detected in 6.9% and 16.7% of FFPE breast cancer tissues, respectively. Clinical factors were not statistically associated with the presence of HCMV and EBV | ||
| 520 | |a CONCLUSION: In this study, we reported EBV and LMP-1 typing in breast carcinoma cases for the first time in Iran. Our findings indicate that HCMV and EBV infections are not associated with the development of breast cancer | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a EBV | |
| 650 | 4 | |a HCMV | |
| 650 | 4 | |a breast cancer | |
| 650 | 4 | |a carcinoma | |
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| 700 | 1 | |a Tavakoli, Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Nafissi, Nahid |e verfasserin |4 aut | |
| 700 | 1 | |a Farahmand, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Ghorbani, Saied |e verfasserin |4 aut | |
| 700 | 1 | |a Moochani, Somayeh Sadat |e verfasserin |4 aut | |
| 700 | 1 | |a Hashemi-Bahremani, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Alebouyeh, Mahmoud Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Monavari, Seyed Hamidreza |e verfasserin |4 aut | |
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