Inflammatory Bowel Disease Patients Who Respond to Treatment with Anti-tumor Necrosis Factor Agents Demonstrate Improvement in Pre-treatment Frailty
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature..
BACKGROUND: Frailty may be a risk factor for complications in inflammatory bowel diseases (IBD) patients. We examined the impact of treatment on IBD patients who were frail prior to treatment and identified predictors of post-treatment change in frailty.
METHODS: In an electronic health record-based cohort of IBD patients initiating anti-tumor necrosis factor (TNF)-α agents, we applied a validated claims-based frailty index to determine frailty in the 1 year prior to and after treatment initiation. We characterized treatment non-response using a composite outcome of IBD-related hospitalization, surgery, change in therapy, or initiation of systemic steroids. We constructed multivariable logistic regression models to identify determinants of post-treatment frailty.
RESULTS: The 1210 patients initiating anti-TNF therapy had a median age of 30 years; 20% were ≥ 50 years. In the first year after anti-TNF initiation, 40% were non-responders. Many more treatment non-responders were frail in the year following treatment compared with treatment responders (27% vs 7%, p < 0.001). Pre-treatment frailty (OR 2.01, 95% CI 1.35-3.00) and prior IBD-related hospitalization (OR 1.63, 95% CI 1.15-2.30) were independently predictive of higher likelihood of post-treatment frailty. Therapy response was associated with a lower likelihood (OR 0.24, 95% CI 0.16-0.34) of post-treatment frailty. Nearly 85% of patients who were frail prior to treatment demonstrated improvement in frailty following treatment CONCLUSIONS: Response to anti-TNF therapy is an important determinant of post-treatment frailty in patients with IBD. Our findings suggest that effectively treating inflammatory states in older patients with IBD may improve frailty.
Errataetall: |
CommentIn: Dig Dis Sci. 2022 Feb;67(2):406-407. - PMID 33932197 |
---|---|
Medienart: |
E-Artikel |
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
---|---|
Enthalten in: |
Digestive diseases and sciences - 67(2022), 2 vom: 01. Feb., Seite 622-628 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Kochar, Bharati D [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 07.03.2022 Date Revised 02.02.2023 published: Print-Electronic CommentIn: Dig Dis Sci. 2022 Feb;67(2):406-407. - PMID 33932197 Citation Status MEDLINE |
---|
doi: |
10.1007/s10620-021-06990-8 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM324853181 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM324853181 | ||
003 | DE-627 | ||
005 | 20231225191208.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1007/s10620-021-06990-8 |2 doi | |
028 | 5 | 2 | |a pubmed24n1082.xml |
035 | |a (DE-627)NLM324853181 | ||
035 | |a (NLM)33932198 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Kochar, Bharati D |e verfasserin |4 aut | |
245 | 1 | 0 | |a Inflammatory Bowel Disease Patients Who Respond to Treatment with Anti-tumor Necrosis Factor Agents Demonstrate Improvement in Pre-treatment Frailty |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 07.03.2022 | ||
500 | |a Date Revised 02.02.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a CommentIn: Dig Dis Sci. 2022 Feb;67(2):406-407. - PMID 33932197 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. | ||
520 | |a BACKGROUND: Frailty may be a risk factor for complications in inflammatory bowel diseases (IBD) patients. We examined the impact of treatment on IBD patients who were frail prior to treatment and identified predictors of post-treatment change in frailty | ||
520 | |a METHODS: In an electronic health record-based cohort of IBD patients initiating anti-tumor necrosis factor (TNF)-α agents, we applied a validated claims-based frailty index to determine frailty in the 1 year prior to and after treatment initiation. We characterized treatment non-response using a composite outcome of IBD-related hospitalization, surgery, change in therapy, or initiation of systemic steroids. We constructed multivariable logistic regression models to identify determinants of post-treatment frailty | ||
520 | |a RESULTS: The 1210 patients initiating anti-TNF therapy had a median age of 30 years; 20% were ≥ 50 years. In the first year after anti-TNF initiation, 40% were non-responders. Many more treatment non-responders were frail in the year following treatment compared with treatment responders (27% vs 7%, p < 0.001). Pre-treatment frailty (OR 2.01, 95% CI 1.35-3.00) and prior IBD-related hospitalization (OR 1.63, 95% CI 1.15-2.30) were independently predictive of higher likelihood of post-treatment frailty. Therapy response was associated with a lower likelihood (OR 0.24, 95% CI 0.16-0.34) of post-treatment frailty. Nearly 85% of patients who were frail prior to treatment demonstrated improvement in frailty following treatment CONCLUSIONS: Response to anti-TNF therapy is an important determinant of post-treatment frailty in patients with IBD. Our findings suggest that effectively treating inflammatory states in older patients with IBD may improve frailty | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Anti-tumor necrosis factor | |
650 | 4 | |a Frailty | |
650 | 4 | |a Function | |
650 | 4 | |a Inflammatory bowel disease | |
650 | 4 | |a Treatment | |
650 | 7 | |a Tumor Necrosis Factor Inhibitors |2 NLM | |
650 | 7 | |a Infliximab |2 NLM | |
650 | 7 | |a B72HH48FLU |2 NLM | |
650 | 7 | |a Adalimumab |2 NLM | |
650 | 7 | |a FYS6T7F842 |2 NLM | |
700 | 1 | |a Cai, Winston |e verfasserin |4 aut | |
700 | 1 | |a Ananthakrishnan, Ashwin N |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Digestive diseases and sciences |d 1989 |g 67(2022), 2 vom: 01. Feb., Seite 622-628 |w (DE-627)NLM000356492 |x 1573-2568 |7 nnns |
773 | 1 | 8 | |g volume:67 |g year:2022 |g number:2 |g day:01 |g month:02 |g pages:622-628 |
856 | 4 | 0 | |u http://dx.doi.org/10.1007/s10620-021-06990-8 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 67 |j 2022 |e 2 |b 01 |c 02 |h 622-628 |