Causes of hospitalisation among a cohort of people with HIV from a London centre followed from 2011 to 2018
BACKGROUND: We describe the spectrum of ICD-10 classified causes for hospitalisations occurring between 2011 and 2018 in a cohort of people living with HIV (PLHIV).
METHODS: This sub-study includes 798 PLHIV participating in the Antiretroviral, Sexual Transmission Risk and Attitudes (ASTRA) questionnaire study who were recruited from a large London centre. A medical record review identified the occurrence and causes of hospitalisation from the date of questionnaire completion (February-December 2011) until 1 June 2018. Up to five causes were classified by an HIV clinician using the ICD-10 system.
RESULTS: There were 274 hospitalisations in 153 people (rate = 5.8/100 person-years; 95% CI: 5.1, 6.5). Causes were wide-ranging; the most common were circulatory (16.8%), digestive (13.1%), respiratory (11.7%), infectious diseases (11.0%), injury/poisoning (10.6%), genitourinary diseases (9.9%) and neoplasms (9.1%). A tenth (27/274) of hospitalisations were related to at least one AIDS-defining illness. Median duration of hospitalisation was 5 days (IQR 2-9). At the time of hospitalisation, median CD4 count was high (510 cells/μl; IQR: 315-739), while median CD4 nadir was relatively low (113 cells/μl; IQR: 40-239). At admission, half of individuals (51%) had a previous AIDS-defining illness and 21% had viral load > 50 copies/ml. Individuals admitted for infectious diseases were particularly likely to have unfavourable HIV-related clinical characteristics (low CD4, viral non-suppression, not on antiretroviral therapy (ART), previous AIDS).
CONCLUSIONS: In the modern combination antiretroviral therapy era, the spectrum of causes of hospitalisation in PLHIV in the UK is wide-ranging, highlighting the importance of holistic care for PLHIV, including prevention, early detection and treatment of comorbidities.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
BMC infectious diseases - 21(2021), 1 vom: 29. Apr., Seite 395 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rein, Sophia M [VerfasserIn] |
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| Links: |
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| Themen: |
AIDS |
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| Anmerkungen: |
Date Completed 10.05.2021 Date Revised 10.05.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s12879-021-06082-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM324796161 |
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| 100 | 1 | |a Rein, Sophia M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Causes of hospitalisation among a cohort of people with HIV from a London centre followed from 2011 to 2018 |
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| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: We describe the spectrum of ICD-10 classified causes for hospitalisations occurring between 2011 and 2018 in a cohort of people living with HIV (PLHIV) | ||
| 520 | |a METHODS: This sub-study includes 798 PLHIV participating in the Antiretroviral, Sexual Transmission Risk and Attitudes (ASTRA) questionnaire study who were recruited from a large London centre. A medical record review identified the occurrence and causes of hospitalisation from the date of questionnaire completion (February-December 2011) until 1 June 2018. Up to five causes were classified by an HIV clinician using the ICD-10 system | ||
| 520 | |a RESULTS: There were 274 hospitalisations in 153 people (rate = 5.8/100 person-years; 95% CI: 5.1, 6.5). Causes were wide-ranging; the most common were circulatory (16.8%), digestive (13.1%), respiratory (11.7%), infectious diseases (11.0%), injury/poisoning (10.6%), genitourinary diseases (9.9%) and neoplasms (9.1%). A tenth (27/274) of hospitalisations were related to at least one AIDS-defining illness. Median duration of hospitalisation was 5 days (IQR 2-9). At the time of hospitalisation, median CD4 count was high (510 cells/μl; IQR: 315-739), while median CD4 nadir was relatively low (113 cells/μl; IQR: 40-239). At admission, half of individuals (51%) had a previous AIDS-defining illness and 21% had viral load > 50 copies/ml. Individuals admitted for infectious diseases were particularly likely to have unfavourable HIV-related clinical characteristics (low CD4, viral non-suppression, not on antiretroviral therapy (ART), previous AIDS) | ||
| 520 | |a CONCLUSIONS: In the modern combination antiretroviral therapy era, the spectrum of causes of hospitalisation in PLHIV in the UK is wide-ranging, highlighting the importance of holistic care for PLHIV, including prevention, early detection and treatment of comorbidities | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a AIDS | |
| 650 | 4 | |a Causes | |
| 650 | 4 | |a Diagnoses | |
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| 650 | 4 | |a Hospitalization | |
| 650 | 4 | |a Morbidity | |
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| 700 | 1 | |a Lampe, Fiona C |e verfasserin |4 aut | |
| 700 | 1 | |a Chaloner, Clinton |e verfasserin |4 aut | |
| 700 | 1 | |a Stafford, Adam |e verfasserin |4 aut | |
| 700 | 1 | |a Rodger, Alison J |e verfasserin |4 aut | |
| 700 | 1 | |a Johnson, Margaret A |e verfasserin |4 aut | |
| 700 | 1 | |a McDonnell, Jeffrey |e verfasserin |4 aut | |
| 700 | 1 | |a Burns, Fiona |e verfasserin |4 aut | |
| 700 | 1 | |a Madge, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Miners, Alec |e verfasserin |4 aut | |
| 700 | 1 | |a Sherr, Lorraine |e verfasserin |4 aut | |
| 700 | 1 | |a Collins, Simon |e verfasserin |4 aut | |
| 700 | 1 | |a Speakman, Andrew |e verfasserin |4 aut | |
| 700 | 1 | |a Phillips, Andrew N |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Colette J |e verfasserin |4 aut | |
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