Combinations of Piperine with Hydroxypropyl-β-Cyclodextrin as a Multifunctional System
Piperine is an alkaloid that has extensive pharmacological activity and impacts other active substances bioavailability due to inhibition of CYP450 enzymes, stimulation of amino acid transporters and P-glycoprotein inhibition. Low solubility and the associated low bioavailability of piperine limit its potential. The combination of piperine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) causes a significant increase in its solubility and, consequently, an increase in permeability through gastrointestinal tract membranes and the blood-brain barrier. X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) were used to characterize interactions between piperine and HP-β-CD. The observed physicochemical changes should be combined with the process of piperine and CD system formation. Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
International journal of molecular sciences - 22(2021), 8 vom: 18. Apr. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Stasiłowicz, Anna [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 24.05.2021 Date Revised 01.04.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/ijms22084195 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Piperine is an alkaloid that has extensive pharmacological activity and impacts other active substances bioavailability due to inhibition of CYP450 enzymes, stimulation of amino acid transporters and P-glycoprotein inhibition. Low solubility and the associated low bioavailability of piperine limit its potential. The combination of piperine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) causes a significant increase in its solubility and, consequently, an increase in permeability through gastrointestinal tract membranes and the blood-brain barrier. X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) were used to characterize interactions between piperine and HP-β-CD. The observed physicochemical changes should be combined with the process of piperine and CD system formation. Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase) | ||
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| 650 | 4 | |a hydroxypropyl-β-cyclodextrin | |
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| 700 | 1 | |a Rosiak, Natalia |e verfasserin |4 aut | |
| 700 | 1 | |a Tykarska, Ewa |e verfasserin |4 aut | |
| 700 | 1 | |a Kozak, Maciej |e verfasserin |4 aut | |
| 700 | 1 | |a Jenczyk, Jacek |e verfasserin |4 aut | |
| 700 | 1 | |a Szulc, Piotr |e verfasserin |4 aut | |
| 700 | 1 | |a Kobus-Cisowska, Joanna |e verfasserin |4 aut | |
| 700 | 1 | |a Lewandowska, Kornelia |e verfasserin |4 aut | |
| 700 | 1 | |a Płazińska, Anita |e verfasserin |4 aut | |
| 700 | 1 | |a Płaziński, Wojciech |e verfasserin |4 aut | |
| 700 | 1 | |a Cielecka-Piontek, Judyta |e verfasserin |4 aut | |
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