An Introduction to Next Generation Sequencing Bioinformatic Analysis in Gut Microbiome Studies
The gut microbiome is a microbial ecosystem which expresses 100 times more genes than the human host and plays an essential role in human health and disease pathogenesis. Since most intestinal microbial species are difficult to culture, next generation sequencing technologies have been widely applied to study the gut microbiome, including 16S rRNA, 18S rRNA, internal transcribed spacer (ITS) sequencing, shotgun metagenomic sequencing, metatranscriptomic sequencing and viromic sequencing. Various software tools were developed to analyze different sequencing data. In this review, we summarize commonly used computational tools for gut microbiome data analysis, which extended our understanding of the gut microbiome in health and diseases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Biomolecules - 11(2021), 4 vom: 02. Apr. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Gao, Bei [VerfasserIn] |
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| Links: |
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| Themen: |
Fungi |
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| Anmerkungen: |
Date Completed 17.09.2021 Date Revised 01.11.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.3390/biom11040530 |
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| funding: |
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NLM324717385 |
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| 520 | |a The gut microbiome is a microbial ecosystem which expresses 100 times more genes than the human host and plays an essential role in human health and disease pathogenesis. Since most intestinal microbial species are difficult to culture, next generation sequencing technologies have been widely applied to study the gut microbiome, including 16S rRNA, 18S rRNA, internal transcribed spacer (ITS) sequencing, shotgun metagenomic sequencing, metatranscriptomic sequencing and viromic sequencing. Various software tools were developed to analyze different sequencing data. In this review, we summarize commonly used computational tools for gut microbiome data analysis, which extended our understanding of the gut microbiome in health and diseases | ||
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| 700 | 1 | |a Shi, Xiaochun |e verfasserin |4 aut | |
| 700 | 1 | |a Tu, Pengcheng |e verfasserin |4 aut | |
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| 700 | 1 | |a Yin, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Nan |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Weishou |e verfasserin |4 aut | |
| 700 | 1 | |a Schnabl, Bernd |e verfasserin |4 aut | |
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