Cleft Lip and Palate in Infants With Prenatal Opioid Exposure
OBJECTIVE: This study examines phenotypic presentation and perioperative outcomes of cleft-related procedures for infants with cleft lip and/or palate (CL/P) and prenatal opioid exposure.
DESIGN: This is a retrospective review of infants with prenatal opioid exposure treated for CL/P from 2008 to 2018.
SETTING: Patients cared for at a tertiary center from 2008 to 2018.
PATIENTS/PARTICIPANTS: Eighteen patients with documented prenatal opioid exposure and CL/P had primary repairs in our unit.
MAIN OUTCOME MEASURE(S): The phenotypes of CL/P were characterized. Demographic data regarding additional exposures, as well as associated medical and social comorbidities were recorded. Outcome variables included operative delays, perioperative complications, and loss of follow-up.
RESULTS: Isolated cleft palate (CP; 67%) was overrepresented among patients with prenatal opioid exposure and CL/P, as was Robin sequence (50% in isolated CP). Fifty-six percent had exposure to additional substances. A majority (67%) had other medical conditions or anomalies, and 17% had known genetic syndromes. Seventy-two percent were in state custody. Thirty-nine percent of exposed patients had delays in their planned operative dates due to medical and/or social factors. There were no postoperative readmissions following cleft procedures. Lack of follow-up was noted in 33% of patients.
CONCLUSIONS: Infants with CL/P who have prenatal opioid exposure are likely to have additional medical conditions and complex social challenges.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
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| Enthalten in: |
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association - 59(2022), 4 vom: 01. Apr., Seite 497-504 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Langa, Olivia [VerfasserIn] |
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| Links: |
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| Themen: |
Analgesics, Opioid |
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| Anmerkungen: |
Date Completed 15.04.2022 Date Revised 22.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1177/10556656211011896 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM324598637 |
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| 500 | |a Date Completed 15.04.2022 | ||
| 500 | |a Date Revised 22.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: This study examines phenotypic presentation and perioperative outcomes of cleft-related procedures for infants with cleft lip and/or palate (CL/P) and prenatal opioid exposure | ||
| 520 | |a DESIGN: This is a retrospective review of infants with prenatal opioid exposure treated for CL/P from 2008 to 2018 | ||
| 520 | |a SETTING: Patients cared for at a tertiary center from 2008 to 2018 | ||
| 520 | |a PATIENTS/PARTICIPANTS: Eighteen patients with documented prenatal opioid exposure and CL/P had primary repairs in our unit | ||
| 520 | |a MAIN OUTCOME MEASURE(S): The phenotypes of CL/P were characterized. Demographic data regarding additional exposures, as well as associated medical and social comorbidities were recorded. Outcome variables included operative delays, perioperative complications, and loss of follow-up | ||
| 520 | |a RESULTS: Isolated cleft palate (CP; 67%) was overrepresented among patients with prenatal opioid exposure and CL/P, as was Robin sequence (50% in isolated CP). Fifty-six percent had exposure to additional substances. A majority (67%) had other medical conditions or anomalies, and 17% had known genetic syndromes. Seventy-two percent were in state custody. Thirty-nine percent of exposed patients had delays in their planned operative dates due to medical and/or social factors. There were no postoperative readmissions following cleft procedures. Lack of follow-up was noted in 33% of patients | ||
| 520 | |a CONCLUSIONS: Infants with CL/P who have prenatal opioid exposure are likely to have additional medical conditions and complex social challenges | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a cleft lip and palate | |
| 650 | 4 | |a neonatal abstinence syndrome | |
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