Antimicrobial photodynamic therapy for oral Candida infection in adult AIDS patients : A pilot clinical trial
Copyright © 2021 Elsevier B.V. All rights reserved..
BACKGROUND: Antimicrobial photodynamic therapy (aPDT) using methylene blue (MB) plus potassium iodide (KI) has been shown to be effective in killing Candida albicans in many in vitro and in vivo studies, however, there are limited reports of clinical investigations. This study aimed to explore the clinical application of aPDT with MB plus KI for the treatment of oral infection caused by C. albicans in adult acquired immune deficiency syndrome (AIDS) patients.
METHODS: A total of 21 adult AIDS patients with C. albicans oral candidiasis were divided into two groups according to MB concentration and received two consecutive aPDT treatments. Immediately before and after the aPDT treatments, C. albicans yeast isolates were recovered to measure the colony-forming units per mL (CFU/mL), biofilm formation, and to analyze the 25S rDNA genotype. Patients were assessed for the clinical recovery of oral lesions and improvement of symptoms.
RESULTS: The Log10 CFU/mL of C. albicans decreased significantly after the second aPDT but not the first aPDT. There was no significant difference between the two MB concentrations. Both aPDT protocols decreased the oral lesions and clinical symptoms with no significant difference after 2-fraction aPDT. The biofilm formation of C. albicans isolates did not change before and after aPDT. The killing efficiency of 2-fraction-aPDT was not associated with either biofilm formation or 25S rDNA genotype.
CONCLUSIONS: Two-fraction-aPDT with MB plus KI could reduce the number of viable C. albicans fungal cells and improve the clinical symptoms of oral candidiasis in adult AIDS patients, regardless of the biofilm formation or 25S rDNA genotype of infected C. albicans isolates.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Photodiagnosis and photodynamic therapy - 34(2021) vom: 01. Juni, Seite 102310 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Du, Meixia [VerfasserIn] |
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| Links: |
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| Themen: |
AIDS |
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| Anmerkungen: |
Date Completed 30.06.2021 Date Revised 30.06.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.pdpdt.2021.102310 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM324551827 |
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| 245 | 1 | 0 | |a Antimicrobial photodynamic therapy for oral Candida infection in adult AIDS patients |b A pilot clinical trial |
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| 500 | |a Date Revised 30.06.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: Antimicrobial photodynamic therapy (aPDT) using methylene blue (MB) plus potassium iodide (KI) has been shown to be effective in killing Candida albicans in many in vitro and in vivo studies, however, there are limited reports of clinical investigations. This study aimed to explore the clinical application of aPDT with MB plus KI for the treatment of oral infection caused by C. albicans in adult acquired immune deficiency syndrome (AIDS) patients | ||
| 520 | |a METHODS: A total of 21 adult AIDS patients with C. albicans oral candidiasis were divided into two groups according to MB concentration and received two consecutive aPDT treatments. Immediately before and after the aPDT treatments, C. albicans yeast isolates were recovered to measure the colony-forming units per mL (CFU/mL), biofilm formation, and to analyze the 25S rDNA genotype. Patients were assessed for the clinical recovery of oral lesions and improvement of symptoms | ||
| 520 | |a RESULTS: The Log10 CFU/mL of C. albicans decreased significantly after the second aPDT but not the first aPDT. There was no significant difference between the two MB concentrations. Both aPDT protocols decreased the oral lesions and clinical symptoms with no significant difference after 2-fraction aPDT. The biofilm formation of C. albicans isolates did not change before and after aPDT. The killing efficiency of 2-fraction-aPDT was not associated with either biofilm formation or 25S rDNA genotype | ||
| 520 | |a CONCLUSIONS: Two-fraction-aPDT with MB plus KI could reduce the number of viable C. albicans fungal cells and improve the clinical symptoms of oral candidiasis in adult AIDS patients, regardless of the biofilm formation or 25S rDNA genotype of infected C. albicans isolates | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a AIDS | |
| 650 | 4 | |a Antimicrobial photodynamic therapy | |
| 650 | 4 | |a Candida albicans | |
| 650 | 4 | |a Clinical trial | |
| 650 | 4 | |a Methylene blue | |
| 650 | 4 | |a Oral candidiasis | |
| 650 | 7 | |a Anti-Infective Agents |2 NLM | |
| 650 | 7 | |a Photosensitizing Agents |2 NLM | |
| 700 | 1 | |a Xuan, Weijun |e verfasserin |4 aut | |
| 700 | 1 | |a Zhen, Xiumei |e verfasserin |4 aut | |
| 700 | 1 | |a He, Lixia |e verfasserin |4 aut | |
| 700 | 1 | |a Lan, Lina |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Shanlin |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Nianning |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Jinmei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Qin, Jianglong |e verfasserin |4 aut | |
| 700 | 1 | |a Lan, Jian |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Huan |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Cuijin |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Yanjun |e verfasserin |4 aut | |
| 700 | 1 | |a R Hamblin, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Liyi |e verfasserin |4 aut | |
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