Exercise tolerance and quality of life in patients with known or suspected coronary artery disease
© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG..
BACKGROUND: Coronary artery disease (CAD) is known to impact on patients' physical and mental health. The relationship between performance on treadmill exercise tolerance test (ETT) and health-related quality of life (HRQL)has never been specifically investigated in the setting of CAD.
METHODS: Consecutive patients undergoing an ETT with the Bruce protocol during a diagnostic workup for CAD (n = 1,631, age 55 ± 12 years) were evaluated. Exercise-related indices were recorded. Detailed information on cardiovascular risk factors and past medical history were obtained. HRQLwas assessed with the use of the validated 36-Item Short Form Survey (SF-36) questionnaire.
RESULTS: Increasing age and the presence of cardiovascular risk factors and comorbidities correlated with lower scores on the physical and mental health component of SF-36(all P < 0.05). Subjects with arrhythmias during exercise and slow recovery of systolic blood pressure had lower scores on the physical health indices or the Social Role Functioning component (P < 0.05). Achieved target heart rate and good exercise tolerance were independently associated with better scores of the physical and mental health domains of SF-36 and overall HRQLscores (β = 0.05 for target HR and PCS-36, β = 1.86 and β = 1.66 per increasing stage of exercise tolerance and PCS-36 and MCS-36, respectively, P < 0.001 for all associations). Ischemic ECG changes were associated with worse scores on Physical Functioning (β = - 3.2, P = 0.02) and Bodily Pain (β = - 4.55, P = 0.026).
CONCLUSION: ETT parameters are associated with HRQL indices in patients evaluated for possible CAD. Physical conditioning may increase patient well-being and could serve as a complementary target in conjunction with cardiovascular drug therapy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation - 30(2021), 9 vom: 24. Sept., Seite 2541-2550 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Katsi, Vasiliki [VerfasserIn] |
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| Links: |
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| Themen: |
Coronary heart disease |
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| Anmerkungen: |
Date Completed 25.11.2021 Date Revised 25.11.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11136-021-02844-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM324474997 |
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| 100 | 1 | |a Katsi, Vasiliki |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Exercise tolerance and quality of life in patients with known or suspected coronary artery disease |
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| 500 | |a Date Revised 25.11.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG. | ||
| 520 | |a BACKGROUND: Coronary artery disease (CAD) is known to impact on patients' physical and mental health. The relationship between performance on treadmill exercise tolerance test (ETT) and health-related quality of life (HRQL)has never been specifically investigated in the setting of CAD | ||
| 520 | |a METHODS: Consecutive patients undergoing an ETT with the Bruce protocol during a diagnostic workup for CAD (n = 1,631, age 55 ± 12 years) were evaluated. Exercise-related indices were recorded. Detailed information on cardiovascular risk factors and past medical history were obtained. HRQLwas assessed with the use of the validated 36-Item Short Form Survey (SF-36) questionnaire | ||
| 520 | |a RESULTS: Increasing age and the presence of cardiovascular risk factors and comorbidities correlated with lower scores on the physical and mental health component of SF-36(all P < 0.05). Subjects with arrhythmias during exercise and slow recovery of systolic blood pressure had lower scores on the physical health indices or the Social Role Functioning component (P < 0.05). Achieved target heart rate and good exercise tolerance were independently associated with better scores of the physical and mental health domains of SF-36 and overall HRQLscores (β = 0.05 for target HR and PCS-36, β = 1.86 and β = 1.66 per increasing stage of exercise tolerance and PCS-36 and MCS-36, respectively, P < 0.001 for all associations). Ischemic ECG changes were associated with worse scores on Physical Functioning (β = - 3.2, P = 0.02) and Bodily Pain (β = - 4.55, P = 0.026) | ||
| 520 | |a CONCLUSION: ETT parameters are associated with HRQL indices in patients evaluated for possible CAD. Physical conditioning may increase patient well-being and could serve as a complementary target in conjunction with cardiovascular drug therapy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Coronary heart disease | |
| 650 | 4 | |a Mental health | |
| 650 | 4 | |a Physical health | |
| 650 | 4 | |a Quality of life | |
| 650 | 4 | |a Treadmill exercise tolerance test | |
| 700 | 1 | |a Georgiopoulos, Georgios |e verfasserin |4 aut | |
| 700 | 1 | |a Mitropoulou, Panagiota |e verfasserin |4 aut | |
| 700 | 1 | |a Kontoangelos, Konstantinos |e verfasserin |4 aut | |
| 700 | 1 | |a Kollia, Zoi |e verfasserin |4 aut | |
| 700 | 1 | |a Tzavara, Chara |e verfasserin |4 aut | |
| 700 | 1 | |a Soulis, Dimitrios |e verfasserin |4 aut | |
| 700 | 1 | |a Toutouzas, Konstantinos |e verfasserin |4 aut | |
| 700 | 1 | |a Oikonomou, Dimitrios |e verfasserin |4 aut | |
| 700 | 1 | |a Aimo, Alberto |e verfasserin |4 aut | |
| 700 | 1 | |a Tsioufis, Konstantinos |e verfasserin |4 aut | |
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