Characterization of pulmonary impairment associated with COVID-19 in patients requiring mechanical ventilation
OBJECTIVE: To detect early respiratory and hemodynamic instability to characterize pulmonary impairment in patients with severe COVID-19.
METHODS: We retrospectively analyzed data collected from COVID-19 patients suffering from acute respiratory failure requiring intubation and mechanical ventilation. We used transpulmonary thermodilution assessment with a PiCCO™ device. We collected demographic, respiratory, hemodynamic and echocardiographic data within the first 48 hours after admission. Descriptive statistics were used to summarize the data.
RESULTS: Fifty-three patients with severe COVID-19 were admitted between March 22nd and April 7th. Twelve of them (22.6%) were monitored with a PiCCO™ device. Upon admission, the global-end diastolic volume indexed was normal (mean 738.8mL ± 209.2) and moderately increased at H48 (879mL ± 179), and the cardiac index was subnormal (2.84 ± 0.65). All patients showed extravascular lung water over 8mL/kg on admission (17.9 ± 8.9). We did not identify any argument for cardiogenic failure.
CONCLUSION: In the case of severe COVID-19 pneumonia, hemodynamic and respiratory presentation is consistent with pulmonary edema without evidence of cardiogenic origin, favoring the diagnosis of acute respiratory distress syndrome.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
|---|---|
| Enthalten in: |
Revista Brasileira de terapia intensiva - 33(2021), 1 vom: 14. Jan., Seite 75-81 |
| Sprache: |
Portugiesisch |
|---|
| Weiterer Titel: |
Caracterização do comprometimento pulmonar associado à COVID-19 em pacientes com necessidade de ventilação mecânica |
|---|
| Beteiligte Personen: |
Virot, Edouard [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 29.04.2021 Date Revised 22.04.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.5935/0103-507X.20210007 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM324409060 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM324409060 | ||
| 003 | DE-627 | ||
| 005 | 20231225190248.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||por c | ||
| 024 | 7 | |a 10.5935/0103-507X.20210007 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1081.xml |
| 035 | |a (DE-627)NLM324409060 | ||
| 035 | |a (NLM)33886855 | ||
| 035 | |a (PII)S0103-507X2021000100075 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a por | ||
| 100 | 1 | |a Virot, Edouard |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Characterization of pulmonary impairment associated with COVID-19 in patients requiring mechanical ventilation |
| 246 | 3 | 3 | |a Caracterização do comprometimento pulmonar associado à COVID-19 em pacientes com necessidade de ventilação mecânica |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 29.04.2021 | ||
| 500 | |a Date Revised 22.04.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To detect early respiratory and hemodynamic instability to characterize pulmonary impairment in patients with severe COVID-19 | ||
| 520 | |a METHODS: We retrospectively analyzed data collected from COVID-19 patients suffering from acute respiratory failure requiring intubation and mechanical ventilation. We used transpulmonary thermodilution assessment with a PiCCO™ device. We collected demographic, respiratory, hemodynamic and echocardiographic data within the first 48 hours after admission. Descriptive statistics were used to summarize the data | ||
| 520 | |a RESULTS: Fifty-three patients with severe COVID-19 were admitted between March 22nd and April 7th. Twelve of them (22.6%) were monitored with a PiCCO™ device. Upon admission, the global-end diastolic volume indexed was normal (mean 738.8mL ± 209.2) and moderately increased at H48 (879mL ± 179), and the cardiac index was subnormal (2.84 ± 0.65). All patients showed extravascular lung water over 8mL/kg on admission (17.9 ± 8.9). We did not identify any argument for cardiogenic failure | ||
| 520 | |a CONCLUSION: In the case of severe COVID-19 pneumonia, hemodynamic and respiratory presentation is consistent with pulmonary edema without evidence of cardiogenic origin, favoring the diagnosis of acute respiratory distress syndrome | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Mathien, Cyrille |e verfasserin |4 aut | |
| 700 | 1 | |a Pointurier, Valentin |e verfasserin |4 aut | |
| 700 | 1 | |a Poidevin, Antoine |e verfasserin |4 aut | |
| 700 | 1 | |a Labro, Guylaine |e verfasserin |4 aut | |
| 700 | 1 | |a Pinto, Luis |e verfasserin |4 aut | |
| 700 | 1 | |a Jandeaux, Louise Marie |e verfasserin |4 aut | |
| 700 | 1 | |a Mootien, Joy |e verfasserin |4 aut | |
| 700 | 1 | |a Kuteifan, Khaldoun |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Revista Brasileira de terapia intensiva |d 1998 |g 33(2021), 1 vom: 14. Jan., Seite 75-81 |w (DE-627)NLM094484147 |x 1982-4335 |7 nnns |
| 773 | 1 | 8 | |g volume:33 |g year:2021 |g number:1 |g day:14 |g month:01 |g pages:75-81 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.5935/0103-507X.20210007 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 33 |j 2021 |e 1 |b 14 |c 01 |h 75-81 | ||