Deformable microparticles for shuttling nanoparticles to the vascular wall
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY)..
Vascular-targeted drug carriers must localize to the wall (i.e., marginate) and adhere to a diseased endothelium to achieve clinical utility. The particle size has been reported as a critical physical property prescribing particle margination in vitro and in vivo blood flows. Different transport process steps yield conflicting requirements-microparticles are optimal for margination, but nanoparticles are better for intracellular or tissue delivery. Here, we evaluate deformable hydrogel microparticles as carriers for transporting nanoparticles to a diseased vascular wall. Depending on microparticle modulus, nanoparticle-loaded poly(ethylene glycol)-based hydrogel microparticles delivered significantly more 50-nm nanoparticles to the vessel wall than freely injected nanoparticles alone, resulting in >3000% delivery increase. This work demonstrates the benefit of optimizing microparticles' efficient margination to enhance nanocarriers' transport to the vascular wall.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
Science advances - 7(2021), 17 vom: 21. Apr. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fish, Margaret B [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Revised 21.10.2023 published: Electronic-Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1126/sciadv.abe0143 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM324374593 |
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| 520 | |a Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). | ||
| 520 | |a Vascular-targeted drug carriers must localize to the wall (i.e., marginate) and adhere to a diseased endothelium to achieve clinical utility. The particle size has been reported as a critical physical property prescribing particle margination in vitro and in vivo blood flows. Different transport process steps yield conflicting requirements-microparticles are optimal for margination, but nanoparticles are better for intracellular or tissue delivery. Here, we evaluate deformable hydrogel microparticles as carriers for transporting nanoparticles to a diseased vascular wall. Depending on microparticle modulus, nanoparticle-loaded poly(ethylene glycol)-based hydrogel microparticles delivered significantly more 50-nm nanoparticles to the vessel wall than freely injected nanoparticles alone, resulting in >3000% delivery increase. This work demonstrates the benefit of optimizing microparticles' efficient margination to enhance nanocarriers' transport to the vascular wall | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Banka, Alison L |e verfasserin |4 aut | |
| 700 | 1 | |a Braunreuther, Margaret |e verfasserin |4 aut | |
| 700 | 1 | |a Fromen, Catherine A |e verfasserin |4 aut | |
| 700 | 1 | |a Kelley, William J |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Adili, Reheman |e verfasserin |4 aut | |
| 700 | 1 | |a Holinstat, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Eniola-Adefeso, Omolola |e verfasserin |4 aut | |
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