A New Stochastic Approach for Modeling Glycemic Disturbances in Type 2 Diabetes
OBJECTIVE: To improve insulin treatment in type 2 diabetes (T2D) using model-based control techniques, the underlying model needs to be individualized to each patient. Due to the impact of unknown meals, exercise and other factors on the blood glucose, it is difficult to utilize available data from continuous glucose monitors (CGMs) for model fitting and parameter estimation purposes.
METHODS: To overcome this problem, we propose a novel method for modeling the glycemic disturbances as a stochastic process. To differentiate meals from other glycemic disturbances, we model the meal intake as a separate stochastic process while encompassing all other disturbances in another stochastic process. Using particle filtering, we validate the model on simulations as well as on clinical data.
RESULTS: Based on simulated CGM data, the residuals generated by the particle filter are white, indicating a good model fit. For the clinical data, we use parameter values estimated based on fasting glucose data. The residuals obtained from clinical CGM data contain correlations up to lag 5.
CONCLUSION: The proposed model is shown to adequately describe the meal-induced glucose fluctuations in simulated CGM data while validations on clinical CGM data show promising results as well.
SIGNIFICANCE: The proposed model may lay the grounds for new ways of utilizing available CGM data, including CGM-based parameter estimation and stochastic optimal control.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:68 |
|---|---|
| Enthalten in: |
IEEE transactions on bio-medical engineering - 68(2021), 10 vom: 31. Okt., Seite 3161-3172 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Clausen, Henrik [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Blood Glucose |
|---|
| Anmerkungen: |
Date Completed 01.11.2021 Date Revised 01.11.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1109/TBME.2021.3074868 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM324363222 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM324363222 | ||
| 003 | DE-627 | ||
| 005 | 20231225190150.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1109/TBME.2021.3074868 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1081.xml |
| 035 | |a (DE-627)NLM324363222 | ||
| 035 | |a (NLM)33881986 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Clausen, Henrik |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A New Stochastic Approach for Modeling Glycemic Disturbances in Type 2 Diabetes |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 01.11.2021 | ||
| 500 | |a Date Revised 01.11.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To improve insulin treatment in type 2 diabetes (T2D) using model-based control techniques, the underlying model needs to be individualized to each patient. Due to the impact of unknown meals, exercise and other factors on the blood glucose, it is difficult to utilize available data from continuous glucose monitors (CGMs) for model fitting and parameter estimation purposes | ||
| 520 | |a METHODS: To overcome this problem, we propose a novel method for modeling the glycemic disturbances as a stochastic process. To differentiate meals from other glycemic disturbances, we model the meal intake as a separate stochastic process while encompassing all other disturbances in another stochastic process. Using particle filtering, we validate the model on simulations as well as on clinical data | ||
| 520 | |a RESULTS: Based on simulated CGM data, the residuals generated by the particle filter are white, indicating a good model fit. For the clinical data, we use parameter values estimated based on fasting glucose data. The residuals obtained from clinical CGM data contain correlations up to lag 5 | ||
| 520 | |a CONCLUSION: The proposed model is shown to adequately describe the meal-induced glucose fluctuations in simulated CGM data while validations on clinical CGM data show promising results as well | ||
| 520 | |a SIGNIFICANCE: The proposed model may lay the grounds for new ways of utilizing available CGM data, including CGM-based parameter estimation and stochastic optimal control | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Blood Glucose |2 NLM | |
| 700 | 1 | |a Knudsen, Torben |e verfasserin |4 aut | |
| 700 | 1 | |a Al Ahdab, Mohamad |e verfasserin |4 aut | |
| 700 | 1 | |a Aradottir, Tinna |e verfasserin |4 aut | |
| 700 | 1 | |a Schmidt, Signe |e verfasserin |4 aut | |
| 700 | 1 | |a Norgaard, Kirsten |e verfasserin |4 aut | |
| 700 | 1 | |a Leth, John |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t IEEE transactions on bio-medical engineering |d 1963 |g 68(2021), 10 vom: 31. Okt., Seite 3161-3172 |w (DE-627)NLM000003913 |x 1558-2531 |7 nnns |
| 773 | 1 | 8 | |g volume:68 |g year:2021 |g number:10 |g day:31 |g month:10 |g pages:3161-3172 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1109/TBME.2021.3074868 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 68 |j 2021 |e 10 |b 31 |c 10 |h 3161-3172 | ||