Randomized Controlled Trials 1 : Design
Today's clinical practice relies on the application of well-designed clinical research, the gold standard test of an intervention being the randomized controlled trial. Principles of the randomized control trial include emphasis on the principal research question, randomization, blinding; definitions of outcome measures, of inclusion and exclusion criteria, and of co-morbid and confounding factors; enrolling an adequate sample size; planning data management and analysis; preventing challenges to trial integrity such as drop-out, drop-in, and bias. The application of pre-trial planning is stressed to ensure the proper application of epidemiological principles resulting in clinical studies that are feasible and generalizable. In addition, funding strategies and trial team composition are discussed.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:2249 |
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Enthalten in: |
Methods in molecular biology (Clifton, N.J.) - 2249(2021) vom: 19., Seite 193-211 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Curtis, Bryan M [VerfasserIn] |
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Links: |
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Themen: |
Blinding |
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Anmerkungen: |
Date Completed 22.06.2021 Date Revised 22.06.2021 published: Print Citation Status MEDLINE |
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doi: |
10.1007/978-1-0716-1138-8_11 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM324264615 |
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