Cross sectional investigation of a COVID-19 outbreak at a London Army barracks : Neutralising antibodies and virus isolation
Crown Copyright © 2020 Published by Elsevier Ltd..
BACKGROUND: Military personnel in enclosed societies are at increased risk of respiratory infections. We investigated an outbreak of Coronavirus Disease 2019 in a London Army barracks early in the pandemic.
METHODS: Army personnel, their families and civilians had nasal and throat swabs for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by reverse transcriptase -polymerase chain reaction (RT-PCR), virus isolation and whole genome sequencing, along with blood samples for SARS-CoV-2 antibodies. All tests were repeated 36 days later.
FINDINGS: During the first visit, 304 (254 Army personnel, 10 family members, 36 civilians, 4 not stated) participated and 24/304 (8%) were SARS-CoV-2 RT-PCR positive. Infectious virus was isolated from 7/24 (29%). Of the 285 who provided a blood sample, 7% (19/285) were antibody positive and 63% (12/19) had neutralising antibodies. Twenty-two (22/34, 64%) individuals with laboratory-confirmed infection were asymptomatic. Nine SARS-CoV-2 RT-PCR positive participants were also antibody positive but those who had neutralising antibodies did not have infectious virus. At the second visit, no new infections were detected, and 13% (25/193) were seropositive, including 52% (13/25) with neutralising antibodies. Risk factors for SARS-CoV-2 antibody positivity included contact with a confirmed case (RR 25.2; 95% CI 14-45), being female (RR 2.5; 95% CI 1.0-6.0) and two-person shared bathroom (RR 2.6; 95% CI 1.1-6.4).
INTERPRETATION: We identified high rates of asymptomatic SARS-CoV-2 infection. Public Health control measures can mitigate spread but virus re-introduction from asymptomatic individuals remains a risk. Most seropositive individuals had neutralising antibodies and infectious virus was not recovered from anyone with neutralising antibodies.
FUNDING: PHE.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2 |
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| Enthalten in: |
The Lancet regional health. Europe - 2(2021) vom: 11. März, Seite 100015 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Taylor, Hannah [VerfasserIn] |
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| Anmerkungen: |
Date Revised 07.11.2023 published: Print Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.lanepe.2020.100015 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM324249217 |
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| 245 | 1 | 0 | |a Cross sectional investigation of a COVID-19 outbreak at a London Army barracks |b Neutralising antibodies and virus isolation |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Crown Copyright © 2020 Published by Elsevier Ltd. | ||
| 520 | |a BACKGROUND: Military personnel in enclosed societies are at increased risk of respiratory infections. We investigated an outbreak of Coronavirus Disease 2019 in a London Army barracks early in the pandemic | ||
| 520 | |a METHODS: Army personnel, their families and civilians had nasal and throat swabs for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by reverse transcriptase -polymerase chain reaction (RT-PCR), virus isolation and whole genome sequencing, along with blood samples for SARS-CoV-2 antibodies. All tests were repeated 36 days later | ||
| 520 | |a FINDINGS: During the first visit, 304 (254 Army personnel, 10 family members, 36 civilians, 4 not stated) participated and 24/304 (8%) were SARS-CoV-2 RT-PCR positive. Infectious virus was isolated from 7/24 (29%). Of the 285 who provided a blood sample, 7% (19/285) were antibody positive and 63% (12/19) had neutralising antibodies. Twenty-two (22/34, 64%) individuals with laboratory-confirmed infection were asymptomatic. Nine SARS-CoV-2 RT-PCR positive participants were also antibody positive but those who had neutralising antibodies did not have infectious virus. At the second visit, no new infections were detected, and 13% (25/193) were seropositive, including 52% (13/25) with neutralising antibodies. Risk factors for SARS-CoV-2 antibody positivity included contact with a confirmed case (RR 25.2; 95% CI 14-45), being female (RR 2.5; 95% CI 1.0-6.0) and two-person shared bathroom (RR 2.6; 95% CI 1.1-6.4) | ||
| 520 | |a INTERPRETATION: We identified high rates of asymptomatic SARS-CoV-2 infection. Public Health control measures can mitigate spread but virus re-introduction from asymptomatic individuals remains a risk. Most seropositive individuals had neutralising antibodies and infectious virus was not recovered from anyone with neutralising antibodies | ||
| 520 | |a FUNDING: PHE | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Wall, William |e verfasserin |4 aut | |
| 700 | 1 | |a Ross, David |e verfasserin |4 aut | |
| 700 | 1 | |a Janarthanan, Roshni |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Liyang |e verfasserin |4 aut | |
| 700 | 1 | |a Aiano, Felicity |e verfasserin |4 aut | |
| 700 | 1 | |a Ellis, Joanna |e verfasserin |4 aut | |
| 700 | 1 | |a Gopal, Robin |e verfasserin |4 aut | |
| 700 | 1 | |a Andrews, Nick |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Monika |e verfasserin |4 aut | |
| 700 | 1 | |a Lackenby, Angie |e verfasserin |4 aut | |
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| 700 | 1 | |a Zambon, Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Ladhani, Shamez N |e verfasserin |4 aut | |
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