All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes
Copyright: © 2020 Hughes AE et al..
Background: Using genetic scores for fasting plasma glucose (FPG GS) and type 2 diabetes (T2D GS), we investigated whether the fasting, 1-hour and 2-hour glucose thresholds from the WHO 2013 criteria for gestational diabetes (GDM) have different implications for genetic susceptibility to raised fasting glucose and type 2 diabetes in women from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) and Atlantic Diabetes in Pregnancy (DIP) studies. Methods: Cases were divided into three subgroups: (i) FPG ≥5.1 mmol/L only, n=222; (ii) 1-hour glucose post 75 g oral glucose load ≥10 mmol/L only, n=154 (iii) 2-hour glucose ≥8.5 mmol/L only, n=73; and (iv) both FPG ≥5.1 mmol/L and either of a 1-hour glucose ≥10 mmol/L or 2-hour glucose ≥8.5 mmol/L, n=172. We compared the FPG and T2D GS of these groups with controls (n=3,091) in HAPO and DIP separately. Results: In HAPO and DIP, the mean FPG GS in women with a FPG ≥5.1 mmol/L, either on its own or with 1-hour glucose ≥10 mmol/L or 2-hour glucose ≥8.5 mmol/L, was higher than controls (all P <0.01). Mean T2D GS in women with a raised FPG alone or with either a raised 1-hour or 2-hour glucose was higher than controls (all P <0.05). GDM defined by 1-hour or 2-hour hyperglycaemia only was also associated with a higher T2D GS than controls (all P <0.05). Conclusions: The different diagnostic categories that are part of the WHO 2013 criteria for GDM identify women with a genetic predisposition to type 2 diabetes as well as a risk for adverse pregnancy outcomes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
Wellcome open research - 5(2020) vom: 18., Seite 175 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hughes, Alice E [VerfasserIn] |
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| Links: |
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| Themen: |
Fasting plasma glucose |
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| Anmerkungen: |
Date Revised 22.04.2021 published: Electronic-eCollection figshare: 10.6084/m9.figshare.14180033 Citation Status PubMed-not-MEDLINE |
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| doi: |
10.12688/wellcomeopenres.16097.2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Hughes, Alice E |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a All thresholds of maternal hyperglycaemia from the WHO 2013 criteria for gestational diabetes identify women with a higher genetic risk for type 2 diabetes |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright: © 2020 Hughes AE et al. | ||
| 520 | |a Background: Using genetic scores for fasting plasma glucose (FPG GS) and type 2 diabetes (T2D GS), we investigated whether the fasting, 1-hour and 2-hour glucose thresholds from the WHO 2013 criteria for gestational diabetes (GDM) have different implications for genetic susceptibility to raised fasting glucose and type 2 diabetes in women from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) and Atlantic Diabetes in Pregnancy (DIP) studies. Methods: Cases were divided into three subgroups: (i) FPG ≥5.1 mmol/L only, n=222; (ii) 1-hour glucose post 75 g oral glucose load ≥10 mmol/L only, n=154 (iii) 2-hour glucose ≥8.5 mmol/L only, n=73; and (iv) both FPG ≥5.1 mmol/L and either of a 1-hour glucose ≥10 mmol/L or 2-hour glucose ≥8.5 mmol/L, n=172. We compared the FPG and T2D GS of these groups with controls (n=3,091) in HAPO and DIP separately. Results: In HAPO and DIP, the mean FPG GS in women with a FPG ≥5.1 mmol/L, either on its own or with 1-hour glucose ≥10 mmol/L or 2-hour glucose ≥8.5 mmol/L, was higher than controls (all P <0.01). Mean T2D GS in women with a raised FPG alone or with either a raised 1-hour or 2-hour glucose was higher than controls (all P <0.05). GDM defined by 1-hour or 2-hour hyperglycaemia only was also associated with a higher T2D GS than controls (all P <0.05). Conclusions: The different diagnostic categories that are part of the WHO 2013 criteria for GDM identify women with a genetic predisposition to type 2 diabetes as well as a risk for adverse pregnancy outcomes | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a type 2 diabetes | |
| 700 | 1 | |a Hayes, M Geoffrey |e verfasserin |4 aut | |
| 700 | 1 | |a Egan, Aoife M |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Kashyap A |e verfasserin |4 aut | |
| 700 | 1 | |a Scholtens, Denise M |e verfasserin |4 aut | |
| 700 | 1 | |a Lowe, Lynn P |e verfasserin |4 aut | |
| 700 | 1 | |a Lowe, William L |c Jr |e verfasserin |4 aut | |
| 700 | 1 | |a Dunne, Fidelma P |e verfasserin |4 aut | |
| 700 | 1 | |a Hattersley, Andrew T |e verfasserin |4 aut | |
| 700 | 1 | |a Freathy, Rachel M |e verfasserin |4 aut | |
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