Obesity as an adipose tissue dysfunction disease and a risk factor for infections - Covid-19 as a case study
Copyright © 2021 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved..
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically relevant, the underlying mechanisms are not fully elucidated. SARS CoV2 enters host cells via the Angiotensin Converting Enzyme 2 receptor, that is also expressed in adipose tissue. Moreover, adipose tissue is also a source of many proinflammatory mediators and adipokines that might enhance the characteristic COVID-19 cytokine storm due to a chronic low-grade inflammatory preconditioning. Further obesity-dependent thoracic mechanical constraints may also incise negatively into the prognosis of obese subjects with COVID-19. This review summarizes the current body of knowledge on the obesity-dependent circumstances triggering an increased risk for COVID-19 severity, and their clinical relevance.
Errataetall: |
CommentIn: Eur J Intern Med. 2021 Sep;91:1-2. - PMID 34226117 |
---|---|
Medienart: |
E-Artikel |
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:91 |
---|---|
Enthalten in: |
European journal of internal medicine - 91(2021) vom: 06. Sept., Seite 3-9 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Landecho, M F [VerfasserIn] |
---|
Links: |
---|
Themen: |
ARDS |
---|
Anmerkungen: |
Date Completed 06.09.2021 Date Revised 01.11.2022 published: Print-Electronic CommentIn: Eur J Intern Med. 2021 Sep;91:1-2. - PMID 34226117 Citation Status MEDLINE |
---|
doi: |
10.1016/j.ejim.2021.03.031 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM324134746 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM324134746 | ||
003 | DE-627 | ||
005 | 20231225185654.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.ejim.2021.03.031 |2 doi | |
028 | 5 | 2 | |a pubmed24n1080.xml |
035 | |a (DE-627)NLM324134746 | ||
035 | |a (NLM)33858724 | ||
035 | |a (PII)S0953-6205(21)00097-2 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Landecho, M F |e verfasserin |4 aut | |
245 | 1 | 0 | |a Obesity as an adipose tissue dysfunction disease and a risk factor for infections - Covid-19 as a case study |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 06.09.2021 | ||
500 | |a Date Revised 01.11.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a CommentIn: Eur J Intern Med. 2021 Sep;91:1-2. - PMID 34226117 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2021 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved. | ||
520 | |a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV2) disease (COVID-19) is a novel threat that hampers life expectancy especially in obese individuals. Though this association is clinically relevant, the underlying mechanisms are not fully elucidated. SARS CoV2 enters host cells via the Angiotensin Converting Enzyme 2 receptor, that is also expressed in adipose tissue. Moreover, adipose tissue is also a source of many proinflammatory mediators and adipokines that might enhance the characteristic COVID-19 cytokine storm due to a chronic low-grade inflammatory preconditioning. Further obesity-dependent thoracic mechanical constraints may also incise negatively into the prognosis of obese subjects with COVID-19. This review summarizes the current body of knowledge on the obesity-dependent circumstances triggering an increased risk for COVID-19 severity, and their clinical relevance | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a ARDS | |
650 | 4 | |a Adipokines | |
650 | 4 | |a Adiponectin | |
650 | 4 | |a Bariatric surgery | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a Cytokine storm | |
650 | 4 | |a Diabetes mellitus | |
650 | 4 | |a Hypertension | |
650 | 4 | |a Leptin | |
650 | 4 | |a Mortality | |
650 | 4 | |a Obesity | |
650 | 4 | |a SARS-CoV-2 | |
700 | 1 | |a Marin-Oto, M |e verfasserin |4 aut | |
700 | 1 | |a Recalde-Zamacona, B |e verfasserin |4 aut | |
700 | 1 | |a Bilbao, I |e verfasserin |4 aut | |
700 | 1 | |a Frühbeck, Gema |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t European journal of internal medicine |d 1997 |g 91(2021) vom: 06. Sept., Seite 3-9 |w (DE-627)NLM089689097 |x 1879-0828 |7 nnns |
773 | 1 | 8 | |g volume:91 |g year:2021 |g day:06 |g month:09 |g pages:3-9 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ejim.2021.03.031 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 91 |j 2021 |b 06 |c 09 |h 3-9 |