Metabolic needs of the kidney graft undergoing normothermic machine perfusion
Copyright © 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved..
Normothermic machine perfusion (NMP) is emerging as a novel preservation strategy. During NMP, the organ is maintained in a metabolically active state that may not only provide superior organ preservation, but that also facilitates viability testing before transplantation, and ex situ resuscitation of marginal kidney grafts. Although the prevailing perfusion protocols for renal NMP are refined from initial pioneering studies concerning short periods of NMP, it could be argued that these protocols are not optimally tailored to address the putatively compromised metabolic plasticity of marginal donor grafts (i.e., in the context of viability testing and/or preservation), or to meet the metabolic prerequisites associated with prolonged perfusions and the required anabolic state in the context of organ regeneration. Herein, we provide a theoretical framework for the metabolic requirements for renal NMP. Aspects are discussed along the lines of carbohydrates, fatty acids, amino acids, and micronutrients required for optimal NMP of an isolated kidney. In addition, considerations for monitoring aspects of metabolic status during NMP are discussed.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:100 |
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| Enthalten in: |
Kidney international - 100(2021), 2 vom: 10. Aug., Seite 301-310 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Arykbaeva, Asel S [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 02.08.2021 Date Revised 02.08.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.kint.2021.04.001 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM324123345 |
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| 520 | |a Copyright © 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Normothermic machine perfusion (NMP) is emerging as a novel preservation strategy. During NMP, the organ is maintained in a metabolically active state that may not only provide superior organ preservation, but that also facilitates viability testing before transplantation, and ex situ resuscitation of marginal kidney grafts. Although the prevailing perfusion protocols for renal NMP are refined from initial pioneering studies concerning short periods of NMP, it could be argued that these protocols are not optimally tailored to address the putatively compromised metabolic plasticity of marginal donor grafts (i.e., in the context of viability testing and/or preservation), or to meet the metabolic prerequisites associated with prolonged perfusions and the required anabolic state in the context of organ regeneration. Herein, we provide a theoretical framework for the metabolic requirements for renal NMP. Aspects are discussed along the lines of carbohydrates, fatty acids, amino acids, and micronutrients required for optimal NMP of an isolated kidney. In addition, considerations for monitoring aspects of metabolic status during NMP are discussed | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
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| 650 | 4 | |a machine perfusion | |
| 650 | 4 | |a metabolism | |
| 650 | 4 | |a normothermic | |
| 650 | 4 | |a organ preservation | |
| 700 | 1 | |a de Vries, Dorottya K |e verfasserin |4 aut | |
| 700 | 1 | |a Doppenberg, Jason B |e verfasserin |4 aut | |
| 700 | 1 | |a Engelse, Marten A |e verfasserin |4 aut | |
| 700 | 1 | |a Hankemeier, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Harms, Amy C |e verfasserin |4 aut | |
| 700 | 1 | |a Wijermars, Leonie G |e verfasserin |4 aut | |
| 700 | 1 | |a Schaapherder, Alexander F |e verfasserin |4 aut | |
| 700 | 1 | |a Bakker, Jaap A |e verfasserin |4 aut | |
| 700 | 1 | |a Ploeg, Rutger J |e verfasserin |4 aut | |
| 700 | 1 | |a Alwayn, Ian P J |e verfasserin |4 aut | |
| 700 | 1 | |a Lindeman, Jan H N |e verfasserin |4 aut | |
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