The "drive to eat" hypothesis : energy expenditure and fat-free mass but not adiposity are associated with milk intake and energy intake in 12 week infants
© The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition..
BACKGROUND: Recent work has challenged the long-held assumption that appetite functions to maintain stable body mass and fat mass (FM), suggesting instead that appetite matches food intake to energy expenditure and its correlate, fat-free mass (FFM). Whether this scenario applies to young infants, in chronic positive energy balance, remains unknown.
OBJECTIVES: To test associations of components of energy expenditure and body composition with milk intake (MI) and energy intake (EI) in 12-week infants, by reanalyzing published cross-sectional data.
METHODS: Data were available for 48 infants. In addition to anthropometric measurements, we assessed MI and EI by test-weighing, sleeping metabolic rate (SMR) by indirect calorimetry, and FFM, FM, and total energy expenditure (TEE) by doubly labeled water. Mean parental height was calculated as a marker of infant growth drive. Correlation and multiple regression analyses were applied.
RESULTS: MI and EI correlated with FFM (r = 0.47 and 0.57, respectively; P < 0.01), but not FM (P > 0.6). MI and EI correlated with SMR (r = 0.42 and 0.53, respectively; P < 0.01) and TEE (r = 0.50 and 0.49, respectively; P < 0.01). SMR and TEE correlated with FFM (r = 0.41 and 0.42, respectively; P < 0.01), but not FM (P > 0.2). In a multiple regression analysis, MI was independently associated with TEE (partial r = 0.39) and FFM (partial r = 0.35). EI showed similar associations. Mean parental height was correlated with weight gain, MI, and EI.
CONCLUSIONS: As in adults, MI and EI in young infants were strongly associated with FFM and with total and sleeping components of energy expenditure, but not with fatness. The infant's growth drive contributed to these associations. This suggests that appetite is regulated by the rate of energy expenditure, the size of energy-using tissues, and tissue deposition rate, and that the high levels of body fat characteristic of infants may not constrain weight gain.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:114 |
|---|---|
| Enthalten in: |
The American journal of clinical nutrition - 114(2021), 2 vom: 02. Aug., Seite 505-514 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Wells, Jonathan C [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Appetite control |
|---|
| Anmerkungen: |
Date Completed 01.09.2021 Date Revised 14.02.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/ajcn/nqab067 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM324060297 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM324060297 | ||
| 003 | DE-627 | ||
| 005 | 20231225185519.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/ajcn/nqab067 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1080.xml |
| 035 | |a (DE-627)NLM324060297 | ||
| 035 | |a (NLM)33851194 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Wells, Jonathan C |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The "drive to eat" hypothesis |b energy expenditure and fat-free mass but not adiposity are associated with milk intake and energy intake in 12 week infants |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 01.09.2021 | ||
| 500 | |a Date Revised 14.02.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. | ||
| 520 | |a BACKGROUND: Recent work has challenged the long-held assumption that appetite functions to maintain stable body mass and fat mass (FM), suggesting instead that appetite matches food intake to energy expenditure and its correlate, fat-free mass (FFM). Whether this scenario applies to young infants, in chronic positive energy balance, remains unknown | ||
| 520 | |a OBJECTIVES: To test associations of components of energy expenditure and body composition with milk intake (MI) and energy intake (EI) in 12-week infants, by reanalyzing published cross-sectional data | ||
| 520 | |a METHODS: Data were available for 48 infants. In addition to anthropometric measurements, we assessed MI and EI by test-weighing, sleeping metabolic rate (SMR) by indirect calorimetry, and FFM, FM, and total energy expenditure (TEE) by doubly labeled water. Mean parental height was calculated as a marker of infant growth drive. Correlation and multiple regression analyses were applied | ||
| 520 | |a RESULTS: MI and EI correlated with FFM (r = 0.47 and 0.57, respectively; P < 0.01), but not FM (P > 0.6). MI and EI correlated with SMR (r = 0.42 and 0.53, respectively; P < 0.01) and TEE (r = 0.50 and 0.49, respectively; P < 0.01). SMR and TEE correlated with FFM (r = 0.41 and 0.42, respectively; P < 0.01), but not FM (P > 0.2). In a multiple regression analysis, MI was independently associated with TEE (partial r = 0.39) and FFM (partial r = 0.35). EI showed similar associations. Mean parental height was correlated with weight gain, MI, and EI | ||
| 520 | |a CONCLUSIONS: As in adults, MI and EI in young infants were strongly associated with FFM and with total and sleeping components of energy expenditure, but not with fatness. The infant's growth drive contributed to these associations. This suggests that appetite is regulated by the rate of energy expenditure, the size of energy-using tissues, and tissue deposition rate, and that the high levels of body fat characteristic of infants may not constrain weight gain | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a appetite control | |
| 650 | 4 | |a energy expenditure | |
| 650 | 4 | |a energy intake | |
| 650 | 4 | |a fat mass | |
| 650 | 4 | |a fat-free mass | |
| 650 | 4 | |a infant | |
| 700 | 1 | |a Davies, Peter S |e verfasserin |4 aut | |
| 700 | 1 | |a Hopkins, Mark |e verfasserin |4 aut | |
| 700 | 1 | |a Blundell, John E |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The American journal of clinical nutrition |d 1954 |g 114(2021), 2 vom: 02. Aug., Seite 505-514 |w (DE-627)NLM000025402 |x 1938-3207 |7 nnns |
| 773 | 1 | 8 | |g volume:114 |g year:2021 |g number:2 |g day:02 |g month:08 |g pages:505-514 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/ajcn/nqab067 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 114 |j 2021 |e 2 |b 02 |c 08 |h 505-514 | ||