Impact of HIV Infection on COVID-19 Outcomes Among Hospitalized Adults in the U.S

Background: Whether HIV infection is associated with differences in clinical outcomes among people hospitalized with COVID-19 is uncertain.

Objective: To evaluate the impact of HIV infection on COVID-19 outcomes among hospitalized patients.

Methods: Using the American Heart Association's COVID-19 Cardiovascular Disease registry, we used hierarchical mixed effects models to assess the association of HIV with in-hospital mortality accounting for patient demographics and comorbidities and clustering by hospital. Secondary outcomes included major adverse cardiac events (MACE), severity of illness, and length of stay (LOS).

Results: The registry included 21,528 hospitalization records of people with confirmed COVID-19 from 107 hospitals in 2020, including 220 people living with HIV (PLWH). PLWH were younger (56.0+/-13.0 versus 61.3+/-17.9 years old) and more likely to be male (72.3% vs 52.7%), Non-Hispanic Black (51.4% vs 25.4%), on Medicaid (44.5% vs 24.5), and active tobacco users (12.7% versus 6.5%).Of the study population, 36 PLWH (16.4%) had in-hospital mortality compared with 3,290 (15.4%) without HIV (Risk ratio 1.06, 95%CI 0.79-1.43; risk difference 0.9%, 95%CI -4.2 to 6.1%; p=0.71). After adjustment for age, sex, race, and insurance, HIV was not associated with in-hospital mortality (aOR 1.13; 95%CI 0.77-1.6; p 0.54) even after adding body mass index and comorbidities (aOR 1.15; 95%CI 0.78-1.70; p=0.48). HIV was not associated with MACE (aOR 0.99, 95%CI 0.69-1.44, p=0.91), severity of illness (aOR 0.96, 95%CI 0.62-1.50, p=0.86), or LOS (aOR 1.03; 95% CI 0.76-1.66, p=0.21).

Conclusion: HIV was not associated with adverse outcomes of COVID-19 including in-hospital mortality, MACE, or severity of illness.

Errataetall:

UpdateIn: This article has been published with doi: 10.1097/qad.0000000000003129

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - year:2021

Enthalten in:

medRxiv : the preprint server for health sciences - (2021) vom: 07. Apr.

Sprache:

Englisch

Beteiligte Personen:

Durstenfeld, Matthew S [VerfasserIn]
Sun, Kaiwen [VerfasserIn]
Ma, Yifei [VerfasserIn]
Rodriguez, Fatima [VerfasserIn]
Secemsky, Eric A [VerfasserIn]
Parikh, Rushi V [VerfasserIn]
Hsue, Priscilla Y [VerfasserIn]

Links:

Volltext

Themen:

COVID-19
HIV
Human immunodeficiency virus
Outcomes
Preprint
SARS-CoV-2

Anmerkungen:

Date Revised 01.04.2024

published: Electronic

UpdateIn: This article has been published with doi: 10.1097/qad.0000000000003129

Citation Status PubMed-not-MEDLINE

doi:

10.1101/2021.04.05.21254938

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM32406022X