Impact of prematurity on the optic nerve
Copyright © 2021. Published by Elsevier Masson SAS..
INTRODUCTION: Thanks to the progress made in the past few years in pediatric intensive care as well as the increased survival of preterm infants, the consequences of premature birth are increasingly well documented. With regard to ophthalmologic complications, retinopathy of prematurity is well described, but the optic nerve may also be affected. The goal of this study is to compare the optic nerves of preterm infants as a function of their gestational period with a control group of the same age.
MATERIALS AND METHODS: We conducted a case-control study pairing a full-term infant with each preterm infant. Inclusion criteria were: any child from 5- to 10-years-old, separated into three sub-groups according to their degree of prematurity. Variables were: cup/disc ratio, ocular biometry, intraocular pressure and RNFL thickness.
RESULTS: Thirty-seven preterm infants and 37 controls were included in the study. The mean age at the time of inclusion was 7.05 years for the preterm group and 7.19 years for the control group. No significant difference was observed in axial length or spherical equivalent (P=0.31 and P=0.98, respectively). No significant difference was observed in pachymetry or intraocular pressure (P=0.28 and P=0.22, respectively). We observed a significant increase of 0.1 in the cup/disc ratio of the preterm group compared to the control group (P<0.05). The preterm group cup/disc ratio was 0.36 versus 0.27 for the control group. No significant difference was observed in the 7 quadrants of RNFL between the two groups. However, when comparing infants born before 28 weeks gestation with the control group, we observed a mean decrease of 14.5 microns in the superior temporal sector (P=0.04), a 9 micron decrease in the global thickness G (P=0.03) and a 12.7 micron decrease in the nasal sector (P=0.01).
CONCLUSIONS: In the case of the studied children (aged 5 to 10), the reduced RNFL fiber thickness is a phenomenon dependent essentially on the stage of prematurity. It would be useful to follow these preterm populations over the long term and to compare them to a matched control group to be able to obtain functional results.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
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| Enthalten in: |
Journal francais d'ophtalmologie - 44(2021), 5 vom: 28. Mai, Seite 703-710 |
| Sprache: |
Französisch |
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| Weiterer Titel: |
Impact de la prématurité sur l’aspect morphologique et tomographique du nerf optique |
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| Beteiligte Personen: |
Bielefeld, V [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 18.08.2021 Date Revised 18.08.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jfo.2020.06.048 |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Date Revised 18.08.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021. Published by Elsevier Masson SAS. | ||
| 520 | |a INTRODUCTION: Thanks to the progress made in the past few years in pediatric intensive care as well as the increased survival of preterm infants, the consequences of premature birth are increasingly well documented. With regard to ophthalmologic complications, retinopathy of prematurity is well described, but the optic nerve may also be affected. The goal of this study is to compare the optic nerves of preterm infants as a function of their gestational period with a control group of the same age | ||
| 520 | |a MATERIALS AND METHODS: We conducted a case-control study pairing a full-term infant with each preterm infant. Inclusion criteria were: any child from 5- to 10-years-old, separated into three sub-groups according to their degree of prematurity. Variables were: cup/disc ratio, ocular biometry, intraocular pressure and RNFL thickness | ||
| 520 | |a RESULTS: Thirty-seven preterm infants and 37 controls were included in the study. The mean age at the time of inclusion was 7.05 years for the preterm group and 7.19 years for the control group. No significant difference was observed in axial length or spherical equivalent (P=0.31 and P=0.98, respectively). No significant difference was observed in pachymetry or intraocular pressure (P=0.28 and P=0.22, respectively). We observed a significant increase of 0.1 in the cup/disc ratio of the preterm group compared to the control group (P<0.05). The preterm group cup/disc ratio was 0.36 versus 0.27 for the control group. No significant difference was observed in the 7 quadrants of RNFL between the two groups. However, when comparing infants born before 28 weeks gestation with the control group, we observed a mean decrease of 14.5 microns in the superior temporal sector (P=0.04), a 9 micron decrease in the global thickness G (P=0.03) and a 12.7 micron decrease in the nasal sector (P=0.01) | ||
| 520 | |a CONCLUSIONS: In the case of the studied children (aged 5 to 10), the reduced RNFL fiber thickness is a phenomenon dependent essentially on the stage of prematurity. It would be useful to follow these preterm populations over the long term and to compare them to a matched control group to be able to obtain functional results | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Nerf optique | |
| 650 | 4 | |a Optic nerve | |
| 650 | 4 | |a Prematurity | |
| 650 | 4 | |a Prématurité | |
| 650 | 4 | |a RNFL | |
| 700 | 1 | |a Rousseau, J |e verfasserin |4 aut | |
| 700 | 1 | |a Denis, C |e verfasserin |4 aut | |
| 700 | 1 | |a Giraud, L |e verfasserin |4 aut | |
| 700 | 1 | |a Vallon, A |e verfasserin |4 aut | |
| 700 | 1 | |a Huet, K |e verfasserin |4 aut | |
| 700 | 1 | |a Lehuede, K |e verfasserin |4 aut | |
| 700 | 1 | |a Konig, R |e verfasserin |4 aut | |
| 700 | 1 | |a Lassalle, D |e verfasserin |4 aut | |
| 700 | 1 | |a Wendel, J |e verfasserin |4 aut | |
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| 700 | 1 | |a Lebranchu, P |e verfasserin |4 aut | |
| 700 | 1 | |a Le Meur, G |e verfasserin |4 aut | |
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