Maternal lipid levels in preeclampsia : singleton vs. twin pregnancies
OBJECTIVE: To compare the maternal lipid levels in preeclampsia (PE) patients between singleton and twin pregnancies.
METHODS: In this retrospective study, pregnant women with PE were divided into singleton group (n = 702) and twin group (n = 198). Serum lipids which include total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured and the TC/HDL-C ratio, TG/HDL-C ratio, and LDL-C/HDL-C ratio were calculated and compared between the two groups. Covariance analysis was used to correct the potential factors affecting serum lipid levels such as maternal age, pre-pregnancy body mass index, gestational weight gain, etc.
RESULTS: The levels of TC, TG, LDL-C, and TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio in twin PE were significantly higher than those in singleton PE group, and there was no significant difference in the level of HDL-C between the two groups. In late-onset PE patients, the lipid levels of TC, TG, LDL-C, and TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio in twin PE group were significantly higher than those in singleton PE group, with no significant difference in the level of HDL-C. However, in early-onset PE patients, there were no significant differences in the lipid levels between the two groups.
CONCLUSIONS: There were more obvious lipid disturbances such as higher levels of TC, TG, LDL-C, and TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio in twin PE group than singleton PE group. The differences of lipid levels appeared mainly in late-onset PE group, while the lipid levels in twin PE group were similar to those in singleton PE group during pregnancy in early-onset PE group.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians - 35(2022), 25 vom: 08. Dez., Seite 6132-6139 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jing, Wang [VerfasserIn] |
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| Links: |
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| Themen: |
Cholesterol, HDL |
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| Anmerkungen: |
Date Completed 23.11.2022 Date Revised 23.11.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/14767058.2021.1907335 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Maternal lipid levels in preeclampsia |b singleton vs. twin pregnancies |
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| 500 | |a Date Revised 23.11.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: To compare the maternal lipid levels in preeclampsia (PE) patients between singleton and twin pregnancies | ||
| 520 | |a METHODS: In this retrospective study, pregnant women with PE were divided into singleton group (n = 702) and twin group (n = 198). Serum lipids which include total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were measured and the TC/HDL-C ratio, TG/HDL-C ratio, and LDL-C/HDL-C ratio were calculated and compared between the two groups. Covariance analysis was used to correct the potential factors affecting serum lipid levels such as maternal age, pre-pregnancy body mass index, gestational weight gain, etc | ||
| 520 | |a RESULTS: The levels of TC, TG, LDL-C, and TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio in twin PE were significantly higher than those in singleton PE group, and there was no significant difference in the level of HDL-C between the two groups. In late-onset PE patients, the lipid levels of TC, TG, LDL-C, and TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio in twin PE group were significantly higher than those in singleton PE group, with no significant difference in the level of HDL-C. However, in early-onset PE patients, there were no significant differences in the lipid levels between the two groups | ||
| 520 | |a CONCLUSIONS: There were more obvious lipid disturbances such as higher levels of TC, TG, LDL-C, and TC/HDL-C ratio, TG/HDL-C ratio, LDL-C/HDL-C ratio in twin PE group than singleton PE group. The differences of lipid levels appeared mainly in late-onset PE group, while the lipid levels in twin PE group were similar to those in singleton PE group during pregnancy in early-onset PE group | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Preeclampsia | |
| 650 | 4 | |a early-onset preeclampsia | |
| 650 | 4 | |a late-onset preeclampsia | |
| 650 | 4 | |a lipid | |
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| 650 | 4 | |a twin pregnancy | |
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| 650 | 7 | |a Cholesterol, HDL |2 NLM | |
| 650 | 7 | |a Triglycerides |2 NLM | |
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| 700 | 1 | |a Yang, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, YangYu |e verfasserin |4 aut | |
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