Lipid metabolism in asthma : Immune regulation and potential therapeutic target
Copyright © 2021 Elsevier Inc. All rights reserved..
Asthma is a chronic inflammatory disease of the lungs that poses a considerable health and socioeconomic burden. Several risk factors work synergistically to affect the progression of asthma. Lipid metabolism, especially in distinct cells such as T cells, macrophages, granulocytes, and non-immune cells, plays an essential role in the pathogenesis of asthma, as lipids are potent signaling molecules that regulate a multitude of cellular response. In this review, we focused on the metabolic pathways of lipid molecules, especially fatty acids and their derivatives, and summarized their roles in various cells during the pathogenesis of asthma along with the current pharmacological agents targeting lipid metabolism.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:364 |
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| Enthalten in: |
Cellular immunology - 364(2021) vom: 28. Juni, Seite 104341 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Wei-Jie [VerfasserIn] |
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| Links: |
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| Themen: |
Asthma |
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| Anmerkungen: |
Date Completed 23.11.2021 Date Revised 23.11.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.cellimm.2021.104341 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM323543979 |
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| 520 | |a Asthma is a chronic inflammatory disease of the lungs that poses a considerable health and socioeconomic burden. Several risk factors work synergistically to affect the progression of asthma. Lipid metabolism, especially in distinct cells such as T cells, macrophages, granulocytes, and non-immune cells, plays an essential role in the pathogenesis of asthma, as lipids are potent signaling molecules that regulate a multitude of cellular response. In this review, we focused on the metabolic pathways of lipid molecules, especially fatty acids and their derivatives, and summarized their roles in various cells during the pathogenesis of asthma along with the current pharmacological agents targeting lipid metabolism | ||
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| 650 | 4 | |a Asthma | |
| 650 | 4 | |a Granulocyte | |
| 650 | 4 | |a Lipid metabolism | |
| 650 | 4 | |a Macrophage | |
| 650 | 4 | |a T cell | |
| 650 | 7 | |a Fatty Acids |2 NLM | |
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| 700 | 1 | |a Wu, Yin-Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Zhi-Hua |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Hua-Hao |e verfasserin |4 aut | |
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