Computed Tomography-Derived Fractional Flow Reserve in Patients With Chronic Coronary Syndrome : A Real-World Cohort Study
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved..
OBJECTIVE: This study aimed to investigate the outcome of computed tomography (CT) angiography with optional CT-derived fractional flow reserve (FFRCT) of intermediate-range coronary artery disease in non-emergent patients referred on a suspicion of chronic coronary syndrome.
METHODS: Patients were classified as high risk and low-intermediate risk according to the presence of typical angina or either atypical or nonangina chest pain. Outcome was assessed as the cumulative incidence proportion of a composite end point of unstable angina pectoris, unplanned revascularization, nonfatal myocardial infarction, and all-cause mortality.
RESULTS: The study included 743 patients. Mean follow-up was 2.2 (range, 0.1-2.5) years. Low-intermediate-risk and high-risk patients who had invasive coronary angiography deferred had comparable proportions of adverse events (1.4% vs 2.6% [P = 0.27]). Adverse events in high-risk patients with FFRCT >0.80 was 3.3% versus 1.4% in patients where no additional testing was performed (P = 0.79).
CONCLUSIONS: Computed tomography-derived fractional flow reserve >0.8 conveys an excellent prognosis. Computed tomography angiography with optional FFRCT allows for the safe cancellation of invasive coronary angiography in high-risk patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
Journal of computer assisted tomography - 45(2021), 3 vom: 01. Mai, Seite 408-414 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kvist, Thomas Vedel [VerfasserIn] |
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| Anmerkungen: |
Date Completed 28.07.2021 Date Revised 28.07.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1097/RCT.0000000000001151 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM323529437 |
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| 100 | 1 | |a Kvist, Thomas Vedel |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Computed Tomography-Derived Fractional Flow Reserve in Patients With Chronic Coronary Syndrome |b A Real-World Cohort Study |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 28.07.2021 | ||
| 500 | |a Date Revised 28.07.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: This study aimed to investigate the outcome of computed tomography (CT) angiography with optional CT-derived fractional flow reserve (FFRCT) of intermediate-range coronary artery disease in non-emergent patients referred on a suspicion of chronic coronary syndrome | ||
| 520 | |a METHODS: Patients were classified as high risk and low-intermediate risk according to the presence of typical angina or either atypical or nonangina chest pain. Outcome was assessed as the cumulative incidence proportion of a composite end point of unstable angina pectoris, unplanned revascularization, nonfatal myocardial infarction, and all-cause mortality | ||
| 520 | |a RESULTS: The study included 743 patients. Mean follow-up was 2.2 (range, 0.1-2.5) years. Low-intermediate-risk and high-risk patients who had invasive coronary angiography deferred had comparable proportions of adverse events (1.4% vs 2.6% [P = 0.27]). Adverse events in high-risk patients with FFRCT >0.80 was 3.3% versus 1.4% in patients where no additional testing was performed (P = 0.79) | ||
| 520 | |a CONCLUSIONS: Computed tomography-derived fractional flow reserve >0.8 conveys an excellent prognosis. Computed tomography angiography with optional FFRCT allows for the safe cancellation of invasive coronary angiography in high-risk patients | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Nørgaard, Bjarne Linde |e verfasserin |4 aut | |
| 700 | 1 | |a Bøtker, Hans Erik |e verfasserin |4 aut | |
| 700 | 1 | |a Mathiassen, Ole Norling |e verfasserin |4 aut | |
| 700 | 1 | |a Grove, Erik Lerkevang |e verfasserin |4 aut | |
| 700 | 1 | |a Parner, Erik |e verfasserin |4 aut | |
| 700 | 1 | |a Jensen, Jesper Møller |e verfasserin |4 aut | |
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