Altered expression of genes related to innate antifungal immunity in the absence of galectin-3
Galectin-3 (Gal-3) is the most studied member of the animal galectin family, which comprises β-galactoside-binding lectins and participates in several cellular events. Its expression in cells involved in innate and adaptive immunity is related to anti- and proinflammatory functions, signaling an important role in inflammatory, infectious, and tumorigenesis processes. Mice deficient in Gal-3 exhibit important phenotypes, but it is unclear whether these phenotypes reflect an impairment of the functions of this protein. Gal-3 plays an important role in modulating the immune response to different pathogenic microorganisms. However, the role of Gal-3 in immunity to infection is still poorly understood. Therefore, we investigated the effects of Gal-3 deletion on the expression of genes involved in the innate immune response in the lungs, spleens, and brains of Gal-3 KO mice. Gene profiling expression analysis suggested that Gal-3 deletion resulted in differentially modulated expression of the genes encoding beta-glucan, mannose and chitin-responsive pattern recognition receptors, signal transduction, inflammation, and phagocytosis. Our data thus suggest the importance of Gal-3 expression in the host innate immune system.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Virulence - 12(2021), 1 vom: 04. Dez., Seite 981-988 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rezende, Caroline Patini [VerfasserIn] |
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| Links: |
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| Themen: |
Antifungal Agents |
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| Anmerkungen: |
Date Completed 16.12.2021 Date Revised 16.12.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1080/21505594.2021.1903212 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM323353401 |
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| 100 | 1 | |a Rezende, Caroline Patini |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Altered expression of genes related to innate antifungal immunity in the absence of galectin-3 |
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| 500 | |a Date Revised 16.12.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Galectin-3 (Gal-3) is the most studied member of the animal galectin family, which comprises β-galactoside-binding lectins and participates in several cellular events. Its expression in cells involved in innate and adaptive immunity is related to anti- and proinflammatory functions, signaling an important role in inflammatory, infectious, and tumorigenesis processes. Mice deficient in Gal-3 exhibit important phenotypes, but it is unclear whether these phenotypes reflect an impairment of the functions of this protein. Gal-3 plays an important role in modulating the immune response to different pathogenic microorganisms. However, the role of Gal-3 in immunity to infection is still poorly understood. Therefore, we investigated the effects of Gal-3 deletion on the expression of genes involved in the innate immune response in the lungs, spleens, and brains of Gal-3 KO mice. Gene profiling expression analysis suggested that Gal-3 deletion resulted in differentially modulated expression of the genes encoding beta-glucan, mannose and chitin-responsive pattern recognition receptors, signal transduction, inflammation, and phagocytosis. Our data thus suggest the importance of Gal-3 expression in the host innate immune system | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Galectin-3 | |
| 650 | 4 | |a antifungal immunity | |
| 650 | 4 | |a gene expression | |
| 650 | 4 | |a gene knockout | |
| 650 | 4 | |a innate immune response | |
| 650 | 7 | |a Antifungal Agents |2 NLM | |
| 650 | 7 | |a Galectin 3 |2 NLM | |
| 650 | 7 | |a Galectins |2 NLM | |
| 700 | 1 | |a Martins Oliveira Brito, Patricia Kellen |e verfasserin |4 aut | |
| 700 | 1 | |a Pessoni, Andre Moreira |e verfasserin |4 aut | |
| 700 | 1 | |a Da Silva, Thiago Aparecido |e verfasserin |4 aut | |
| 700 | 1 | |a Goldman, Gustavo H |e verfasserin |4 aut | |
| 700 | 1 | |a Almeida, Fausto |e verfasserin |4 aut | |
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