Macrophages expressing TREM-1 are involved in the progression of HPV16-related oropharyngeal squamous cell carcinoma
INTRODUCTION: Many types of research have been performed to improve the diagnosis, therapy, and prognosis of oropharyngeal carcinomas (OP-SCCs). Since they arise in lymphoid-rich areas and intense lymphocytic infiltration has been related to a better prognosis, a TREM-1 putative function in tumour progression and survival has been hypothesized.
MATERIALS AND METHODS: Twenty-seven human papillomavirus (HPV) 16+ OP-SCC specimens have been analyzed to relate TREM-1 expression with histiocytic and lymphocytic markers, HPV presence and patients' outcome.
RESULTS: No differences have been shown between intratumoral and stromal CD4+ cells, while intratumoral CD8+ lymphocytes are higher with respect to the tumour stroma (p = .0005). CD68+ cells are more than CD35+ and TREM-1+; their presence is related to CD35± and TREM-1± histiocytes (p = .005 and .026, respectively). Intratumoral CD4+ lymphocytes are higher in p16+ cases (11/27) than in p16- (p = .042); moreover, p16 positivity correlates to a better survival (p = .034). CD4+, CD8+ and CD35+ cells have no impact on survival, while CD68 expression heavily influences progression and bad outcome (p = .037). TREM-1 positivity also leads to worst overall survival (p = .001): peritumoral expression and death-cause relationship are always significant, particularly when the cause is OP-SCC (p = .000).
CONCLUSION: While p16 shows to better stratify HPV16+ patients' outcome, TREM-1+ macrophages suggest their key importance in HPV-related OP-SCCs progression.KEY MESSAGESTREM-1 positivity correlates to the worst overall survival of HPV16-positive OPSCCs-affected patients.p16-positive HPV16 related OPSCCs patients have a better prognosis with respect to p16-negative ones.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:53 |
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| Enthalten in: |
Annals of medicine - 53(2021), 1 vom: 26. Dez., Seite 541-550 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Azzimonti, Barbara [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 13.10.2021 Date Revised 02.11.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1080/07853890.2021.1905872 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM323251145 |
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| 100 | 1 | |a Azzimonti, Barbara |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Macrophages expressing TREM-1 are involved in the progression of HPV16-related oropharyngeal squamous cell carcinoma |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Revised 02.11.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a INTRODUCTION: Many types of research have been performed to improve the diagnosis, therapy, and prognosis of oropharyngeal carcinomas (OP-SCCs). Since they arise in lymphoid-rich areas and intense lymphocytic infiltration has been related to a better prognosis, a TREM-1 putative function in tumour progression and survival has been hypothesized | ||
| 520 | |a MATERIALS AND METHODS: Twenty-seven human papillomavirus (HPV) 16+ OP-SCC specimens have been analyzed to relate TREM-1 expression with histiocytic and lymphocytic markers, HPV presence and patients' outcome | ||
| 520 | |a RESULTS: No differences have been shown between intratumoral and stromal CD4+ cells, while intratumoral CD8+ lymphocytes are higher with respect to the tumour stroma (p = .0005). CD68+ cells are more than CD35+ and TREM-1+; their presence is related to CD35± and TREM-1± histiocytes (p = .005 and .026, respectively). Intratumoral CD4+ lymphocytes are higher in p16+ cases (11/27) than in p16- (p = .042); moreover, p16 positivity correlates to a better survival (p = .034). CD4+, CD8+ and CD35+ cells have no impact on survival, while CD68 expression heavily influences progression and bad outcome (p = .037). TREM-1 positivity also leads to worst overall survival (p = .001): peritumoral expression and death-cause relationship are always significant, particularly when the cause is OP-SCC (p = .000) | ||
| 520 | |a CONCLUSION: While p16 shows to better stratify HPV16+ patients' outcome, TREM-1+ macrophages suggest their key importance in HPV-related OP-SCCs progression.KEY MESSAGESTREM-1 positivity correlates to the worst overall survival of HPV16-positive OPSCCs-affected patients.p16-positive HPV16 related OPSCCs patients have a better prognosis with respect to p16-negative ones | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Human papillomavirus (HPV) | |
| 650 | 4 | |a oropharyngeal squamous cell carcinoma (OP-SCCs) | |
| 650 | 4 | |a peritumoral and intratumoral infiltration | |
| 650 | 4 | |a triggering receptor expressed on myeloid cells-1 (TREM-1) | |
| 650 | 4 | |a tumoral microenvironment (TME) | |
| 650 | 7 | |a Triggering Receptor Expressed on Myeloid Cells-1 |2 NLM | |
| 700 | 1 | |a Raimondo, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Squarzanti, Diletta Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Rosso, Tiziana |e verfasserin |4 aut | |
| 700 | 1 | |a Zanetta, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Aluffi Valletti, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Chiusa, Luigi |e verfasserin |4 aut | |
| 700 | 1 | |a Masini, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Pecorari, Giancarlo |e verfasserin |4 aut | |
| 700 | 1 | |a Airoldi, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Krengli, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Giovarelli, Mirella |e verfasserin |4 aut | |
| 700 | 1 | |a Valente, Guido |e verfasserin |4 aut | |
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