Heme oxygenase-1 in blood and saliva during acute psychosis : A pilot study
Copyright © 2021 Elsevier B.V. All rights reserved..
Despite the extensive prevalence of psychosis and schizophrenia spectrum disorders, their biological underpinnings remain largely unexplained. Recently, the overproduction of heme oxygenase-1 (HO-1), an enzyme that catalyzes the degradation of heme, was associated with oxidative stress and a neurologic phenotype similar to schizophrenia in transgenic mice. We sought to evaluate, by comparing patients experiencing an acute psychotic episode, and age/sex-matched healthy control participants, whether there was an association between HO-1 overexpression and psychosis. This cross-sectional pilot study included 16 patients and 17 control participants. Enzyme-linked immunosorbent assay and quantitative real-time polymerase chain reaction were used to quantify HO-1 expression in blood and saliva. Four psychiatric questionnaires were used to measure psychiatric symptoms in participants. Higher levels of salivary HO-1 expression were detected in patients experiencing an acute psychotic episode when compared to control participants (84.01 vs. 61.26 ng/ml, p = 0.026), but plasma and lymphocyte HO-1 expression did not significantly differ between groups. Overexpression of HO-1 in saliva specimens was also positively associated with psychiatric symptom severity and disability. The overexpression of HO-1 in the saliva of patients with psychosis suggests that it may serve as a potential biomarker for this symptom which should be explored in larger clinical trials.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:299 |
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| Enthalten in: |
Psychiatry research - 299(2021) vom: 05. Mai, Seite 113857 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bertrand, Thomas [VerfasserIn] |
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| Links: |
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| Themen: |
EC 1.14.14.18 |
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| Anmerkungen: |
Date Completed 25.08.2021 Date Revised 31.05.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.psychres.2021.113857 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2021 Elsevier B.V. All rights reserved. | ||
| 520 | |a Despite the extensive prevalence of psychosis and schizophrenia spectrum disorders, their biological underpinnings remain largely unexplained. Recently, the overproduction of heme oxygenase-1 (HO-1), an enzyme that catalyzes the degradation of heme, was associated with oxidative stress and a neurologic phenotype similar to schizophrenia in transgenic mice. We sought to evaluate, by comparing patients experiencing an acute psychotic episode, and age/sex-matched healthy control participants, whether there was an association between HO-1 overexpression and psychosis. This cross-sectional pilot study included 16 patients and 17 control participants. Enzyme-linked immunosorbent assay and quantitative real-time polymerase chain reaction were used to quantify HO-1 expression in blood and saliva. Four psychiatric questionnaires were used to measure psychiatric symptoms in participants. Higher levels of salivary HO-1 expression were detected in patients experiencing an acute psychotic episode when compared to control participants (84.01 vs. 61.26 ng/ml, p = 0.026), but plasma and lymphocyte HO-1 expression did not significantly differ between groups. Overexpression of HO-1 in saliva specimens was also positively associated with psychiatric symptom severity and disability. The overexpression of HO-1 in the saliva of patients with psychosis suggests that it may serve as a potential biomarker for this symptom which should be explored in larger clinical trials | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Heme oxygenase-1 | |
| 650 | 4 | |a Oxidative stress | |
| 650 | 4 | |a Psychosis | |
| 650 | 4 | |a Schizophrenia | |
| 650 | 7 | |a Heme Oxygenase-1 |2 NLM | |
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| 700 | 1 | |a Kothari, Vimal |e verfasserin |4 aut | |
| 700 | 1 | |a Mohit, Shrisha |e verfasserin |4 aut | |
| 700 | 1 | |a Galindez, Carmela |e verfasserin |4 aut | |
| 700 | 1 | |a Liberman, Adrienne |e verfasserin |4 aut | |
| 700 | 1 | |a Glass, Judy |e verfasserin |4 aut | |
| 700 | 1 | |a Velly, Ana M |e verfasserin |4 aut | |
| 700 | 1 | |a Gornitsky, Mervyn |e verfasserin |4 aut | |
| 700 | 1 | |a Looper, Karl |e verfasserin |4 aut | |
| 700 | 1 | |a Rej, Soham |e verfasserin |4 aut | |
| 700 | 1 | |a Schipper, Hyman M |e verfasserin |4 aut | |
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