Predictors of severe COVID-19 in kidney transplant recipients in the different epidemic waves : Analysis of the Spanish Registry
© 2021 The American Society of Transplantation and the American Society of Transplant Surgeons..
SARS-CoV-2 infection has produced high mortality in kidney transplant (KT) recipients, especially in the elderly. Until December 2020, 1011 KT with COVID-19 have been prospectively included in the Spanish Registry and followed until recovery or death. In multivariable analysis, age, pneumonia, and KT performed ≤6 months before COVID-19 were predictors of death, whereas gastrointestinal symptoms were protective. Survival analysis showed significant increasing mortality risk in four subgroups according to recipient age and time after KT (age <65 years and posttransplant time >6 months, age <65 and time ≤6, age ≥65 and time >6 and age ≥65 and time ≤6): mortality rates were, respectively, 11.3%, 24.5%, 35.4%, and 54.5% (p < .001). Patients were significantly younger, presented less pneumonia, and received less frequently specific anti-COVID-19 treatment in the second wave (July-December) than in the first one (March-June). Overall mortality was lower in the second wave (15.1 vs. 27.4%, p < .001) but similar in critical patients (66.7% vs. 58.1%, p = .29). The interaction between age and time post-KT should be considered when selecting recipients for transplantation in the COVID-19 pandemic. Advanced age and a recent KT should foster strict protective measures, including vaccination.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
|---|---|
| Enthalten in: |
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 21(2021), 7 vom: 20. Juli, Seite 2573-2582 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Villanego, Florentino [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Clinical research/practice |
|---|
| Anmerkungen: |
Date Completed 05.07.2021 Date Revised 28.03.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1111/ajt.16579 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM323123279 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM323123279 | ||
| 003 | DE-627 | ||
| 005 | 20231225183511.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/ajt.16579 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1077.xml |
| 035 | |a (DE-627)NLM323123279 | ||
| 035 | |a (NLM)33756067 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Villanego, Florentino |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Predictors of severe COVID-19 in kidney transplant recipients in the different epidemic waves |b Analysis of the Spanish Registry |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 05.07.2021 | ||
| 500 | |a Date Revised 28.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 The American Society of Transplantation and the American Society of Transplant Surgeons. | ||
| 520 | |a SARS-CoV-2 infection has produced high mortality in kidney transplant (KT) recipients, especially in the elderly. Until December 2020, 1011 KT with COVID-19 have been prospectively included in the Spanish Registry and followed until recovery or death. In multivariable analysis, age, pneumonia, and KT performed ≤6 months before COVID-19 were predictors of death, whereas gastrointestinal symptoms were protective. Survival analysis showed significant increasing mortality risk in four subgroups according to recipient age and time after KT (age <65 years and posttransplant time >6 months, age <65 and time ≤6, age ≥65 and time >6 and age ≥65 and time ≤6): mortality rates were, respectively, 11.3%, 24.5%, 35.4%, and 54.5% (p < .001). Patients were significantly younger, presented less pneumonia, and received less frequently specific anti-COVID-19 treatment in the second wave (July-December) than in the first one (March-June). Overall mortality was lower in the second wave (15.1 vs. 27.4%, p < .001) but similar in critical patients (66.7% vs. 58.1%, p = .29). The interaction between age and time post-KT should be considered when selecting recipients for transplantation in the COVID-19 pandemic. Advanced age and a recent KT should foster strict protective measures, including vaccination | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a clinical research/practice | |
| 650 | 4 | |a infection and infectious agents - viral | |
| 650 | 4 | |a kidney transplantation/nephrology | |
| 650 | 4 | |a patient survival | |
| 700 | 1 | |a Mazuecos, Auxiliadora |e verfasserin |4 aut | |
| 700 | 1 | |a Pérez-Flores, Isabel M |e verfasserin |4 aut | |
| 700 | 1 | |a Moreso, Francesc |e verfasserin |4 aut | |
| 700 | 1 | |a Andrés, Amado |e verfasserin |4 aut | |
| 700 | 1 | |a Jiménez-Martín, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Molina, María |e verfasserin |4 aut | |
| 700 | 1 | |a Canal, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Cámara, Luis A |e verfasserin |4 aut | |
| 700 | 1 | |a Zárraga, Sofía |e verfasserin |4 aut | |
| 700 | 1 | |a Ruiz-Fuentes, María Del Carmen |e verfasserin |4 aut | |
| 700 | 1 | |a Aladrén, María José |e verfasserin |4 aut | |
| 700 | 1 | |a Melilli, Edoardo |e verfasserin |4 aut | |
| 700 | 1 | |a López, Verónica |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Álvarez, Emilio |e verfasserin |4 aut | |
| 700 | 1 | |a Crespo, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Pascual, Julio |e verfasserin |4 aut | |
| 700 | 0 | |a Spanish Society of Nephrology COVID-19 Group |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons |d 2001 |g 21(2021), 7 vom: 20. Juli, Seite 2573-2582 |w (DE-627)NLM119667924 |x 1600-6143 |7 nnns |
| 773 | 1 | 8 | |g volume:21 |g year:2021 |g number:7 |g day:20 |g month:07 |g pages:2573-2582 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/ajt.16579 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 21 |j 2021 |e 7 |b 20 |c 07 |h 2573-2582 | ||