The role of increased FGF21 in VLDL-TAG secretion and thermogenic gene expression in mice under protein malnutrition
© The Author(s) 2021. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry..
Protein malnutrition promotes hepatic lipid accumulation in growing animals. In these animals, fibroblast growth factor 21 (FGF21) rapidly increases in the liver and circulation and plays a protective role in hepatic lipid accumulation. To investigate the mechanism by which FGF21 protects against liver lipid accumulation under protein malnutrition, we determined whether upregulated FGF21 promotes the thermogenesis or secretion of very-low-density lipoprotein (VLDL)-triacylglycerol (TAG). The results showed that protein malnutrition decreased VLDL-TAG secretion, but the upregulation of FGF21 did not oppose this effect. In addition, protein malnutrition increased expression of the thermogenic gene uncoupling protein 1 in inguinal white adipose and brown adipose tissue in an FGF21-dependent manner. However, surgically removing inguinal white adipose tissue did not affect liver triglyceride levels in protein-malnourished mice. These data suggest that FGF21 stimulates thermogenesis under protein malnutrition, but this is not the causative factor underlying the protective role of FGF21 against liver lipid accumulation.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:85 |
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Enthalten in: |
Bioscience, biotechnology, and biochemistry - 85(2021), 5 vom: 24. Apr., Seite 1104-1113 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Ozaki-Masuzawa, Yori [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 06.08.2021 Date Revised 06.08.2021 published: Print Citation Status MEDLINE |
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doi: |
10.1093/bbb/zbab030 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM323073840 |
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100 | 1 | |a Ozaki-Masuzawa, Yori |e verfasserin |4 aut | |
245 | 1 | 4 | |a The role of increased FGF21 in VLDL-TAG secretion and thermogenic gene expression in mice under protein malnutrition |
264 | 1 | |c 2021 | |
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500 | |a Date Completed 06.08.2021 | ||
500 | |a Date Revised 06.08.2021 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © The Author(s) 2021. Published by Oxford University Press on behalf of Japan Society for Bioscience, Biotechnology, and Agrochemistry. | ||
520 | |a Protein malnutrition promotes hepatic lipid accumulation in growing animals. In these animals, fibroblast growth factor 21 (FGF21) rapidly increases in the liver and circulation and plays a protective role in hepatic lipid accumulation. To investigate the mechanism by which FGF21 protects against liver lipid accumulation under protein malnutrition, we determined whether upregulated FGF21 promotes the thermogenesis or secretion of very-low-density lipoprotein (VLDL)-triacylglycerol (TAG). The results showed that protein malnutrition decreased VLDL-TAG secretion, but the upregulation of FGF21 did not oppose this effect. In addition, protein malnutrition increased expression of the thermogenic gene uncoupling protein 1 in inguinal white adipose and brown adipose tissue in an FGF21-dependent manner. However, surgically removing inguinal white adipose tissue did not affect liver triglyceride levels in protein-malnourished mice. These data suggest that FGF21 stimulates thermogenesis under protein malnutrition, but this is not the causative factor underlying the protective role of FGF21 against liver lipid accumulation | ||
650 | 4 | |a Journal Article | |
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650 | 7 | |a Ppargc1a protein, mouse |2 NLM | |
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700 | 1 | |a Kosaka, Hiroki |e verfasserin |4 aut | |
700 | 1 | |a Abiru, Rino |e verfasserin |4 aut | |
700 | 1 | |a Toda, Yumiko |e verfasserin |4 aut | |
700 | 1 | |a Kawabata, Kota |e verfasserin |4 aut | |
700 | 1 | |a Nagata, Mari |e verfasserin |4 aut | |
700 | 1 | |a Hara, Shohei |e verfasserin |4 aut | |
700 | 1 | |a Konishi, Morichika |e verfasserin |4 aut | |
700 | 1 | |a Itoh, Nobuyuki |e verfasserin |4 aut | |
700 | 1 | |a Hosono, Takashi |e verfasserin |4 aut | |
700 | 1 | |a Takenaka, Asako |e verfasserin |4 aut | |
700 | 1 | |a Seki, Taiichiro |e verfasserin |4 aut | |
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