Magneto-Based Synergetic Therapy for Implant-Associated Infections via Biofilm Disruption and Innate Immunity Regulation
© 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH..
Implant-associated infections (IAIs) are a common cause of orthopedic surgery failure due to microbial biofilm-induced antibiotic-resistance and innate immune inactivation. Thus, the destruction of microbial biofilm plays a key role in reducing IAIs. Herein, first, a magneto-based synergetic therapy (MST) is proposed and demonstrated against IAIs based on biofilm destruction. Under an alternating magnetic field (AMF), CoFe2O4MnFe2O4 nanoparticles (MNPs), with a rather strong magnetic hyperthermal capacity, can generate sufficient thermal effect to cause dense biofilm dispersal. Loosened biofilms provide channels through which nitrosothiol-coated MNPs (MNP-SNOs) can penetrate. Subsequently, thermosensitive nitrosothiols rapidly release nitric oxide (NO) inside biofilms, thus efficiently killing sessile bacteria under the magnetothermal effect of MNPs. More importantly, MNP-SNOs can trigger macrophage-related immunity to prevent the relapse of IAIs by exposing the infected foci to a consistent innate immunomodulatory effect. The notable anti-infection effect of this nanoplatform is also confirmed in a rat IAI model. This work presents the promising potential of combining magnetothermal therapy with immunotherapy, for the effective and durable control and elimination of IAIs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 8(2021), 6 vom: 05. März, Seite 2004010 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Jiaxing [VerfasserIn] |
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| Links: |
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| Themen: |
Immunotherapy |
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| Anmerkungen: |
Date Revised 31.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1002/advs.202004010 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH. | ||
| 520 | |a Implant-associated infections (IAIs) are a common cause of orthopedic surgery failure due to microbial biofilm-induced antibiotic-resistance and innate immune inactivation. Thus, the destruction of microbial biofilm plays a key role in reducing IAIs. Herein, first, a magneto-based synergetic therapy (MST) is proposed and demonstrated against IAIs based on biofilm destruction. Under an alternating magnetic field (AMF), CoFe2O4MnFe2O4 nanoparticles (MNPs), with a rather strong magnetic hyperthermal capacity, can generate sufficient thermal effect to cause dense biofilm dispersal. Loosened biofilms provide channels through which nitrosothiol-coated MNPs (MNP-SNOs) can penetrate. Subsequently, thermosensitive nitrosothiols rapidly release nitric oxide (NO) inside biofilms, thus efficiently killing sessile bacteria under the magnetothermal effect of MNPs. More importantly, MNP-SNOs can trigger macrophage-related immunity to prevent the relapse of IAIs by exposing the infected foci to a consistent innate immunomodulatory effect. The notable anti-infection effect of this nanoplatform is also confirmed in a rat IAI model. This work presents the promising potential of combining magnetothermal therapy with immunotherapy, for the effective and durable control and elimination of IAIs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a immunotherapy | |
| 650 | 4 | |a implant‐associated infections | |
| 650 | 4 | |a magnetic nanoparticles | |
| 650 | 4 | |a magneto‐based synergetic therapy | |
| 650 | 4 | |a nitric oxide | |
| 700 | 1 | |a Wang, Lingtian |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Jiong |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Jinhui |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Jin |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Dajun |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Jia, Weitao |e verfasserin |4 aut | |
| 700 | 1 | |a Shi, Jianlin |e verfasserin |4 aut | |
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