Left Ventricular Longitudinal Strain in Characterization and Outcome Assessment of Mixed Aortic Valve Disease Phenotypes
Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved..
OBJECTIVES: The aims of this study were to characterize the interplay between mixed aortic valve disease (MAVD) phenotypes (defined by concomitant severities of aortic stenosis and aortic regurgitation) and left ventricular global longitudinal strain (LV-GLS), and to assess the prognostic utility of LV-GLS in MAVD.
BACKGROUND: Little is known about the way LV-GLS separates MAVD phenotypes and if it is associated with their outcomes.
METHODS: This observational cohort study evaluated 783 consecutive adult patients with left ventricular ejection fraction ≥50% and MAVD, which was defined as coexisting with at least moderate aortic stenosis and at least moderate aortic regurgitation. We measured the conventional echocardiographic variables and average LV-GLS from apical long, 2- and 4-chamber views. The primary endpoint was all-cause mortality.
RESULTS: Mean age of patients was 69 ± 15 years, and 58% were male. Mean LV-GLS was -14.7 ± 2.9%. In total, 458 patients (59%) underwent aortic valve replacement at a median period of 50 days (25th to 75th percentile range: 6 to 560 days). During a median follow-up period of 5.6 years (25th to 75th percentile range: 1.8 to 9.4 years), 391 patients (50%) died. When stratified patients into tertiles according to LV-GLS values, patients with worse LV-GLS had worse outcomes (p < 0.001). LV-GLS was independently associated with mortality (hazard ratio: 1.09; 95% confidential intervals: 1.04 to 1.14; p < 0.001), with the relationship between LV-GLS and mortality being linear.
CONCLUSIONS: LV-GLS is associated with all-cause mortality. LV-GLS may be useful for risk stratification in patients with MAVD.
| Errataetall: |
CommentIn: JACC Cardiovasc Imaging. 2021 Jul;14(7):1335-1337. - PMID 33865765 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
JACC. Cardiovascular imaging - 14(2021), 7 vom: 17. Juli, Seite 1324-1334 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Saijo, Yoshihito [VerfasserIn] |
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| Links: |
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| Themen: |
Global longitudinal strain |
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| Anmerkungen: |
Date Completed 08.10.2021 Date Revised 08.10.2021 published: Print-Electronic CommentIn: JACC Cardiovasc Imaging. 2021 Jul;14(7):1335-1337. - PMID 33865765 Citation Status MEDLINE |
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| doi: |
10.1016/j.jcmg.2021.01.020 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM323005446 |
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| 245 | 1 | 0 | |a Left Ventricular Longitudinal Strain in Characterization and Outcome Assessment of Mixed Aortic Valve Disease Phenotypes |
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| 500 | |a CommentIn: JACC Cardiovasc Imaging. 2021 Jul;14(7):1335-1337. - PMID 33865765 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVES: The aims of this study were to characterize the interplay between mixed aortic valve disease (MAVD) phenotypes (defined by concomitant severities of aortic stenosis and aortic regurgitation) and left ventricular global longitudinal strain (LV-GLS), and to assess the prognostic utility of LV-GLS in MAVD | ||
| 520 | |a BACKGROUND: Little is known about the way LV-GLS separates MAVD phenotypes and if it is associated with their outcomes | ||
| 520 | |a METHODS: This observational cohort study evaluated 783 consecutive adult patients with left ventricular ejection fraction ≥50% and MAVD, which was defined as coexisting with at least moderate aortic stenosis and at least moderate aortic regurgitation. We measured the conventional echocardiographic variables and average LV-GLS from apical long, 2- and 4-chamber views. The primary endpoint was all-cause mortality | ||
| 520 | |a RESULTS: Mean age of patients was 69 ± 15 years, and 58% were male. Mean LV-GLS was -14.7 ± 2.9%. In total, 458 patients (59%) underwent aortic valve replacement at a median period of 50 days (25th to 75th percentile range: 6 to 560 days). During a median follow-up period of 5.6 years (25th to 75th percentile range: 1.8 to 9.4 years), 391 patients (50%) died. When stratified patients into tertiles according to LV-GLS values, patients with worse LV-GLS had worse outcomes (p < 0.001). LV-GLS was independently associated with mortality (hazard ratio: 1.09; 95% confidential intervals: 1.04 to 1.14; p < 0.001), with the relationship between LV-GLS and mortality being linear | ||
| 520 | |a CONCLUSIONS: LV-GLS is associated with all-cause mortality. LV-GLS may be useful for risk stratification in patients with MAVD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a global longitudinal strain | |
| 650 | 4 | |a mixed aortic valve disease | |
| 650 | 4 | |a prognostic value | |
| 650 | 4 | |a speckle tracking | |
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| 700 | 1 | |a Conic, Julijana Z |e verfasserin |4 aut | |
| 700 | 1 | |a Desai, Milind Y |e verfasserin |4 aut | |
| 700 | 1 | |a Johnston, Douglas |e verfasserin |4 aut | |
| 700 | 1 | |a Roselli, Eric E |e verfasserin |4 aut | |
| 700 | 1 | |a Grimm, Richard A |e verfasserin |4 aut | |
| 700 | 1 | |a Svensson, Lars G |e verfasserin |4 aut | |
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| 700 | 1 | |a Popović, Zoran B |e verfasserin |4 aut | |
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