Analysis of Three Mutations in Italian Strains of SARS-CoV-2 : Implications for Pathogenesis
© 2021 S. Karger AG, Basel..
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting >220 countries around the world, with >80 million cases registered and >1.8 million deaths.
OBJECTIVE: As several vaccines are still being developed and 2 have been approved, it is particularly important to perform evolutionary surveillance to identify mutations potentially affecting vaccine efficacy.
METHODS: DynaMut server has been used to evaluate the impact of the mutation found on SARS-CoV-2 isolates available on GISAID.
RESULTS: In this article, we analyze whole genomes sequenced from Italian patients, and we report the characterization of 3 mutations, one of which presents in the spike protein.
CONCLUSION: The mutations analyzed in this article can be useful to evaluate the evolution of SARS-CoV-2.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:66 |
|---|---|
| Enthalten in: |
Chemotherapy - 66(2021), 1-2 vom: 26., Seite 33-37 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Benvenuto, Domenico [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Bioinformatic |
|---|
| Anmerkungen: |
Date Completed 15.06.2021 Date Revised 29.11.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1159/000515342 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM322923794 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM322923794 | ||
| 003 | DE-627 | ||
| 005 | 20231225183054.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1159/000515342 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1076.xml |
| 035 | |a (DE-627)NLM322923794 | ||
| 035 | |a (NLM)33735872 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Benvenuto, Domenico |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Analysis of Three Mutations in Italian Strains of SARS-CoV-2 |b Implications for Pathogenesis |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 15.06.2021 | ||
| 500 | |a Date Revised 29.11.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021 S. Karger AG, Basel. | ||
| 520 | |a BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped virus initially detected in Wuhan in December 2019, responsible for coronavirus disease 2019 (COVID-19), a respiratory syndrome currently affecting >220 countries around the world, with >80 million cases registered and >1.8 million deaths | ||
| 520 | |a OBJECTIVE: As several vaccines are still being developed and 2 have been approved, it is particularly important to perform evolutionary surveillance to identify mutations potentially affecting vaccine efficacy | ||
| 520 | |a METHODS: DynaMut server has been used to evaluate the impact of the mutation found on SARS-CoV-2 isolates available on GISAID | ||
| 520 | |a RESULTS: In this article, we analyze whole genomes sequenced from Italian patients, and we report the characterization of 3 mutations, one of which presents in the spike protein | ||
| 520 | |a CONCLUSION: The mutations analyzed in this article can be useful to evaluate the evolution of SARS-CoV-2 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bioinformatic | |
| 650 | 4 | |a Coronavirus disease 2019 | |
| 650 | 4 | |a Evolutionary analysis | |
| 650 | 4 | |a Protein modeling | |
| 650 | 4 | |a Syndrome coronavirus 2 | |
| 650 | 7 | |a Spike Glycoprotein, Coronavirus |2 NLM | |
| 700 | 1 | |a Benedetti, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Demir, Ayse Banu |e verfasserin |4 aut | |
| 700 | 1 | |a Ciccozzi, Massimo |e verfasserin |4 aut | |
| 700 | 1 | |a Zella, Davide |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Chemotherapy |d 1965 |g 66(2021), 1-2 vom: 26., Seite 33-37 |w (DE-627)NLM000137006 |x 1421-9794 |7 nnns |
| 773 | 1 | 8 | |g volume:66 |g year:2021 |g number:1-2 |g day:26 |g pages:33-37 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1159/000515342 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 66 |j 2021 |e 1-2 |b 26 |h 33-37 | ||