Surface modification by poly(ethylene glycol) with different end-grafted groups : Experimental and theoretical study
Dihydroxyphenylalanine (DOPA) is extensively reported to be a surface-independent anchor molecule in bioadhesive surface modification and antifouling biomaterial fabrication. However, the mechanisms of DOPA adsorption on versatile substrates and the comparison between experimental results and theoretical results are less addressed. We report the adsorption of DOPA anchored monomethoxy poly(ethylene glycol) (DOPA-mPEG) on substrates and surface wettability as well as antifouling property in comparison with thiol and hydroxyl anchored mPEG (mPEG-SH and mPEG-OH). Gold and hydroxylated silicon were used as model substrates to study the adsorptions of mPEGs. The experimental results showed that the DOPA-mPEG showed higher affinity to both gold and silicon wafers, and the DOPA-mPEG modified surfaces had higher resistance to protein adsorption than those of mPEG-SH and mPEG-OH. It is revealed that the surface wettability is primary for surface fouling, while polymer flexibility is the secondary parameter. We present ab initio calculations of the adsorption of mEGs with different end-functionalities on Au and hydroxylated silicon wafer (Si-OH), where the binding energies are obtained. It is established that monomethoxy ethylene glycol (mEG) with DOPA terminal DOPA-mEG is clearly favored for the adsorption with both gold and Si-OH surfaces due to the bidentate Au-O interactions and the bidentate O-H bond interactions, in agreement with experimental evidence.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:16 |
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| Enthalten in: |
Biointerphases - 16(2021), 2 vom: 16. März, Seite 021002 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Han, Xia [VerfasserIn] |
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| Links: |
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| Themen: |
3WJQ0SDW1A |
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| Anmerkungen: |
Date Completed 24.12.2021 Date Revised 24.12.2021 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1116/6.0000647 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM322831350 |
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| 245 | 1 | 0 | |a Surface modification by poly(ethylene glycol) with different end-grafted groups |b Experimental and theoretical study |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 24.12.2021 | ||
| 500 | |a Date Revised 24.12.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Dihydroxyphenylalanine (DOPA) is extensively reported to be a surface-independent anchor molecule in bioadhesive surface modification and antifouling biomaterial fabrication. However, the mechanisms of DOPA adsorption on versatile substrates and the comparison between experimental results and theoretical results are less addressed. We report the adsorption of DOPA anchored monomethoxy poly(ethylene glycol) (DOPA-mPEG) on substrates and surface wettability as well as antifouling property in comparison with thiol and hydroxyl anchored mPEG (mPEG-SH and mPEG-OH). Gold and hydroxylated silicon were used as model substrates to study the adsorptions of mPEGs. The experimental results showed that the DOPA-mPEG showed higher affinity to both gold and silicon wafers, and the DOPA-mPEG modified surfaces had higher resistance to protein adsorption than those of mPEG-SH and mPEG-OH. It is revealed that the surface wettability is primary for surface fouling, while polymer flexibility is the secondary parameter. We present ab initio calculations of the adsorption of mEGs with different end-functionalities on Au and hydroxylated silicon wafer (Si-OH), where the binding energies are obtained. It is established that monomethoxy ethylene glycol (mEG) with DOPA terminal DOPA-mEG is clearly favored for the adsorption with both gold and Si-OH surfaces due to the bidentate Au-O interactions and the bidentate O-H bond interactions, in agreement with experimental evidence | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Polyethylene Glycols |2 NLM | |
| 650 | 7 | |a 3WJQ0SDW1A |2 NLM | |
| 650 | 7 | |a Dihydroxyphenylalanine |2 NLM | |
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| 650 | 7 | |a Gold |2 NLM | |
| 650 | 7 | |a 7440-57-5 |2 NLM | |
| 650 | 7 | |a monomethoxypolyethylene glycol |2 NLM | |
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| 700 | 1 | |a Yuan, Zhaobin |e verfasserin |4 aut | |
| 700 | 1 | |a Niu, Yapeng |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Xueqian |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Honglai |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:16 |g year:2021 |g number:2 |g day:16 |g month:03 |g pages:021002 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1116/6.0000647 |3 Volltext |
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