Effectiveness and Safety of Long-Term Dupilumab Treatment in Elderly Patients with Atopic Dermatitis : A Multicenter Real-Life Observational Study
OBJECTIVE: The objective of this study was to assess the effectiveness and safety of dupilumab in treating elderly patients with atopic dermatitis from baseline to 52 weeks.
METHODS: A retrospective observational real-life study was conducted in a group of elderly patients with severe atopic dermatitis treated with dupilumab for 52 weeks. Inclusion criteria were: age ≥ 65 years; diagnosis of atopic dermatitis made by an expert dermatologist; Eczema Area and Severity Index ≥ 24; and a contraindication, side effects, or failure to respond to cyclosporine. The primary outcome was the mean percentage reduction in the Eczema Area and Severity Index score from baseline to week 52. Secondary measures included the mean percentage reduction in the Pruritus and Sleep Numerical Rating Scales and the Dermatology Life Quality Index, and the types and rates of adverse events from baseline to week 52.
RESULTS: One hundred and five patients were eligible for the study. Flexural dermatitis was the most frequent clinical phenotype (63.8%). The coexistence of more than one clinical phenotype was found in 70/105 (66.6%) patients. We observed a reduction in all disease severity scores from baseline to week 52 (p < 0.001). Adverse events were recorded in 30/105 (28.6%) patients, with conjunctivitis and injection-site reaction the most frequent.
CONCLUSIONS: In this study, dupilumab is an effective and safe treatment for the long-term management of atopic dermatitis in patients aged over 65 years.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
American journal of clinical dermatology - 22(2021), 4 vom: 16. Juli, Seite 581-586 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Patruno, Cataldo [VerfasserIn] |
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| Links: |
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| Themen: |
420K487FSG |
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| Anmerkungen: |
Date Completed 13.09.2021 Date Revised 13.09.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1007/s40257-021-00597-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM322819806 |
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| 245 | 1 | 0 | |a Effectiveness and Safety of Long-Term Dupilumab Treatment in Elderly Patients with Atopic Dermatitis |b A Multicenter Real-Life Observational Study |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 13.09.2021 | ||
| 500 | |a Date Revised 13.09.2021 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: The objective of this study was to assess the effectiveness and safety of dupilumab in treating elderly patients with atopic dermatitis from baseline to 52 weeks | ||
| 520 | |a METHODS: A retrospective observational real-life study was conducted in a group of elderly patients with severe atopic dermatitis treated with dupilumab for 52 weeks. Inclusion criteria were: age ≥ 65 years; diagnosis of atopic dermatitis made by an expert dermatologist; Eczema Area and Severity Index ≥ 24; and a contraindication, side effects, or failure to respond to cyclosporine. The primary outcome was the mean percentage reduction in the Eczema Area and Severity Index score from baseline to week 52. Secondary measures included the mean percentage reduction in the Pruritus and Sleep Numerical Rating Scales and the Dermatology Life Quality Index, and the types and rates of adverse events from baseline to week 52 | ||
| 520 | |a RESULTS: One hundred and five patients were eligible for the study. Flexural dermatitis was the most frequent clinical phenotype (63.8%). The coexistence of more than one clinical phenotype was found in 70/105 (66.6%) patients. We observed a reduction in all disease severity scores from baseline to week 52 (p < 0.001). Adverse events were recorded in 30/105 (28.6%) patients, with conjunctivitis and injection-site reaction the most frequent | ||
| 520 | |a CONCLUSIONS: In this study, dupilumab is an effective and safe treatment for the long-term management of atopic dermatitis in patients aged over 65 years | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Observational Study | |
| 650 | 7 | |a Antibodies, Monoclonal, Humanized |2 NLM | |
| 650 | 7 | |a dupilumab |2 NLM | |
| 650 | 7 | |a 420K487FSG |2 NLM | |
| 700 | 1 | |a Fabbrocini, Gabriella |e verfasserin |4 aut | |
| 700 | 1 | |a Longo, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Argenziano, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrucci, Silvia Mariel |e verfasserin |4 aut | |
| 700 | 1 | |a Stingeni, Luca |e verfasserin |4 aut | |
| 700 | 1 | |a Peris, Ketty |e verfasserin |4 aut | |
| 700 | 1 | |a Ortoncelli, Michela |e verfasserin |4 aut | |
| 700 | 1 | |a Offidani, Annamaria |e verfasserin |4 aut | |
| 700 | 1 | |a Amoruso, Giuseppe Fabrizio |e verfasserin |4 aut | |
| 700 | 1 | |a Talamonti, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Girolomoni, Giampiero |e verfasserin |4 aut | |
| 700 | 1 | |a Grieco, Teresa |e verfasserin |4 aut | |
| 700 | 1 | |a Iannone, Michela |e verfasserin |4 aut | |
| 700 | 1 | |a Nettis, Eustachio |e verfasserin |4 aut | |
| 700 | 1 | |a Foti, Caterina |e verfasserin |4 aut | |
| 700 | 1 | |a Rongioletti, Franco |e verfasserin |4 aut | |
| 700 | 1 | |a Corazza, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Veneri, Michele Delli |e verfasserin |4 aut | |
| 700 | 1 | |a Napolitano, Maddalena |e verfasserin |4 aut | |
| 700 | 0 | |a Dupilumab for Atopic Dermatitis of the Elderly (DADE) Study Group |e verfasserin |4 aut | |
| 700 | 1 | |a Angileri, L |e investigator |4 oth | |
| 700 | 1 | |a Bianchelli, T |e investigator |4 oth | |
| 700 | 1 | |a Borghi, A |e investigator |4 oth | |
| 700 | 1 | |a Calabrese, G |e investigator |4 oth | |
| 700 | 1 | |a Chello, C |e investigator |4 oth | |
| 700 | 1 | |a Dal Bello, G |e investigator |4 oth | |
| 700 | 1 | |a Dastoli, S |e investigator |4 oth | |
| 700 | 1 | |a Ferrillo, M |e investigator |4 oth | |
| 700 | 1 | |a Galluzzo, M |e investigator |4 oth | |
| 700 | 1 | |a Gori, N |e investigator |4 oth | |
| 700 | 1 | |a Hansel, K |e investigator |4 oth | |
| 700 | 1 | |a Macchia, L |e investigator |4 oth | |
| 700 | 1 | |a Piras, V |e investigator |4 oth | |
| 700 | 1 | |a Provenzano, E |e investigator |4 oth | |
| 700 | 1 | |a Ribero, S |e investigator |4 oth | |
| 700 | 1 | |a Romanelli, M |e investigator |4 oth | |
| 700 | 1 | |a Romita, P |e investigator |4 oth | |
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