Outcomes after Descemet membrane endothelial keratoplasty over a period of 7 years at a tertiary referral center : endothelial cell density, central corneal thickness, and visual acuity
© 2021. The Author(s)..
PURPOSE: To better assess clinical trajectories of patients with or without ocular comorbidity after Descemet membrane endothelial keratoplasty.
BACKGROUND: To report on the outcomes of eyes with differing starting conditions following surgery.
DESIGN: Retrospective study at a University Eye Hospital.
PARTICIPANTS: 361 eyes separated into group 1 (n=229; eyes with endothelial disease only) and group 2 (n=132; eyes with additional ocular comorbid conditions, such as herpetic eye disease 18/132 (13.6%), glaucoma 16/132 (12.1%), dry age-related macular degeneration 14/132 (10.6%), epiretinal membranes 10/132 (7.6%), and wet age-related macular degeneration 9/132 (6.8%)).
METHODS: Consecutive eyes that underwent Descemet membrane endothelial keratoplasty over a follow-up period of up to 7 years at a tertiary referral center were reviewed. Main outcome measures were best-corrected visual acuity, postoperative complications, graft survival, central corneal thickness, and endothelial cell density.
RESULTS: Postoperative best-corrected visual acuity at year 1 improved in both groups significantly (Wilcoxon signed rank test: group 1, p =.002; .63 to .23 logMAR; group 2, p <.001; 1.15 to .87 logMAR) with a group difference in favor of group 1 (p =.009, Mann-Whitney-Wilcoxon). A decrease of the endothelial cell density and central corneal thickness was noted at postoperative year 1 for both groups (paired t-tests (group 1, p <.001; group 2, p =.045) and paired t-tests (group 1, p <.001; group 2, p =.003). Complications were less common, and graft longevity was superior in group 1.
CONCLUSION: Eyes with different starting conditions might experience a visual improvement and benefit from surgery. Descemet membrane endothelial keratoplasty is a valid treatment for endothelial disorders in manifold of eyes. Further long-term studies are required.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:259 |
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| Enthalten in: |
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie - 259(2021), 7 vom: 27. Juli, Seite 1907-1914 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bayyoud, Tarek [VerfasserIn] |
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| Links: |
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| Themen: |
Central corneal thickness |
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| Anmerkungen: |
Date Completed 18.08.2021 Date Revised 18.08.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00417-021-05152-w |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Bayyoud, Tarek |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Outcomes after Descemet membrane endothelial keratoplasty over a period of 7 years at a tertiary referral center |b endothelial cell density, central corneal thickness, and visual acuity |
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| 500 | |a Date Completed 18.08.2021 | ||
| 500 | |a Date Revised 18.08.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s). | ||
| 520 | |a PURPOSE: To better assess clinical trajectories of patients with or without ocular comorbidity after Descemet membrane endothelial keratoplasty | ||
| 520 | |a BACKGROUND: To report on the outcomes of eyes with differing starting conditions following surgery | ||
| 520 | |a DESIGN: Retrospective study at a University Eye Hospital | ||
| 520 | |a PARTICIPANTS: 361 eyes separated into group 1 (n=229; eyes with endothelial disease only) and group 2 (n=132; eyes with additional ocular comorbid conditions, such as herpetic eye disease 18/132 (13.6%), glaucoma 16/132 (12.1%), dry age-related macular degeneration 14/132 (10.6%), epiretinal membranes 10/132 (7.6%), and wet age-related macular degeneration 9/132 (6.8%)) | ||
| 520 | |a METHODS: Consecutive eyes that underwent Descemet membrane endothelial keratoplasty over a follow-up period of up to 7 years at a tertiary referral center were reviewed. Main outcome measures were best-corrected visual acuity, postoperative complications, graft survival, central corneal thickness, and endothelial cell density | ||
| 520 | |a RESULTS: Postoperative best-corrected visual acuity at year 1 improved in both groups significantly (Wilcoxon signed rank test: group 1, p =.002; .63 to .23 logMAR; group 2, p <.001; 1.15 to .87 logMAR) with a group difference in favor of group 1 (p =.009, Mann-Whitney-Wilcoxon). A decrease of the endothelial cell density and central corneal thickness was noted at postoperative year 1 for both groups (paired t-tests (group 1, p <.001; group 2, p =.045) and paired t-tests (group 1, p <.001; group 2, p =.003). Complications were less common, and graft longevity was superior in group 1 | ||
| 520 | |a CONCLUSION: Eyes with different starting conditions might experience a visual improvement and benefit from surgery. Descemet membrane endothelial keratoplasty is a valid treatment for endothelial disorders in manifold of eyes. Further long-term studies are required | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Central corneal thickness | |
| 650 | 4 | |a Descemet membrane endothelial keratoplasty | |
| 650 | 4 | |a Endothelial cell density | |
| 650 | 4 | |a Visual acuity | |
| 700 | 1 | |a Gelisken, Faik |e verfasserin |4 aut | |
| 700 | 1 | |a Rohrbach, Jens Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Blumenstock, Gunnar |e verfasserin |4 aut | |
| 700 | 1 | |a Bartz-Schmidt, Karl Ulrich |e verfasserin |4 aut | |
| 700 | 1 | |a Thaler, Sebastian |e verfasserin |4 aut | |
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