Household Severe Acute Respiratory Syndrome Coronavirus 2 Transmission and Children : A Network Prospective Study
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com..
BACKGROUND: The role of children in household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear. We describe the epidemiological and clinical characteristics of children with coronavirus disease 2019 (COVID-19) in Catalonia, Spain, and investigate the household transmission dynamics.
METHODS: A prospective, observational, multicenter study was performed during summer and school periods (1 July 2020-31 October 2020) to analyze epidemiological and clinical features and viral household transmission dynamics in COVID-19 patients aged <16 years. A pediatric index case was established when a child was the first individual infected. Secondary cases were defined when another household member tested positive for SARS-CoV-2 before the child. The secondary attack rate (SAR) was calculated, and logistic regression was used to assess associations between transmission risk factors and SARS-CoV-2 infection.
RESULTS: The study included 1040 COVID-19 patients. Almost half (47.2%) were asymptomatic, 10.8% had comorbidities, and 2.6% required hospitalization. No deaths were reported. Viral transmission was common among household members (62.3%). More than 70% (756/1040) of pediatric cases were secondary to an adult, whereas 7.7% (80/1040) were index cases. The SAR was significantly lower in households with COVID-19 pediatric index cases during the school period relative to summer (P = .02) and compared to adults (P = .006). No individual or environmental risk factors associated with the SAR.
CONCLUSIONS: Children are unlikely to cause household COVID-19 clusters or be major drivers of the pandemic, even if attending school. Interventions aimed at children are expected to have a small impact on reducing SARS-CoV-2 transmission.
Errataetall: | |
---|---|
Medienart: |
E-Artikel |
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:73 |
---|---|
Enthalten in: |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 73(2021), 6 vom: 15. Sept., Seite e1261-e1269 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Soriano-Arandes, Antoni [VerfasserIn] |
---|
Links: |
---|
Themen: |
Child |
---|
Anmerkungen: |
Date Completed 23.09.2021 Date Revised 11.03.2022 published: Print CommentIn: Clin Infect Dis. 2021 Jun 18;:. - PMID 34145451 Citation Status MEDLINE |
---|
doi: |
10.1093/cid/ciab228 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM322660203 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM322660203 | ||
003 | DE-627 | ||
005 | 20231225182517.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1093/cid/ciab228 |2 doi | |
028 | 5 | 2 | |a pubmed24n1075.xml |
035 | |a (DE-627)NLM322660203 | ||
035 | |a (NLM)33709135 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Soriano-Arandes, Antoni |e verfasserin |4 aut | |
245 | 1 | 0 | |a Household Severe Acute Respiratory Syndrome Coronavirus 2 Transmission and Children |b A Network Prospective Study |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 23.09.2021 | ||
500 | |a Date Revised 11.03.2022 | ||
500 | |a published: Print | ||
500 | |a CommentIn: Clin Infect Dis. 2021 Jun 18;:. - PMID 34145451 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com. | ||
520 | |a BACKGROUND: The role of children in household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains unclear. We describe the epidemiological and clinical characteristics of children with coronavirus disease 2019 (COVID-19) in Catalonia, Spain, and investigate the household transmission dynamics | ||
520 | |a METHODS: A prospective, observational, multicenter study was performed during summer and school periods (1 July 2020-31 October 2020) to analyze epidemiological and clinical features and viral household transmission dynamics in COVID-19 patients aged <16 years. A pediatric index case was established when a child was the first individual infected. Secondary cases were defined when another household member tested positive for SARS-CoV-2 before the child. The secondary attack rate (SAR) was calculated, and logistic regression was used to assess associations between transmission risk factors and SARS-CoV-2 infection | ||
520 | |a RESULTS: The study included 1040 COVID-19 patients. Almost half (47.2%) were asymptomatic, 10.8% had comorbidities, and 2.6% required hospitalization. No deaths were reported. Viral transmission was common among household members (62.3%). More than 70% (756/1040) of pediatric cases were secondary to an adult, whereas 7.7% (80/1040) were index cases. The SAR was significantly lower in households with COVID-19 pediatric index cases during the school period relative to summer (P = .02) and compared to adults (P = .006). No individual or environmental risk factors associated with the SAR | ||
520 | |a CONCLUSIONS: Children are unlikely to cause household COVID-19 clusters or be major drivers of the pandemic, even if attending school. Interventions aimed at children are expected to have a small impact on reducing SARS-CoV-2 transmission | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Multicenter Study | |
650 | 4 | |a SARS-CoV-2 | |
650 | 4 | |a child | |
650 | 4 | |a coronavirus | |
650 | 4 | |a household | |
650 | 4 | |a transmission | |
700 | 1 | |a Gatell, Anna |e verfasserin |4 aut | |
700 | 1 | |a Serrano, Pepe |e verfasserin |4 aut | |
700 | 1 | |a Biosca, Mireia |e verfasserin |4 aut | |
700 | 1 | |a Campillo, Ferran |e verfasserin |4 aut | |
700 | 1 | |a Capdevila, Ramon |e verfasserin |4 aut | |
700 | 1 | |a Fàbrega, Anna |e verfasserin |4 aut | |
700 | 1 | |a Lobato, Zulema |e verfasserin |4 aut | |
700 | 1 | |a López, Núria |e verfasserin |4 aut | |
700 | 1 | |a Moreno, Ana Mª |e verfasserin |4 aut | |
700 | 1 | |a Poblet, Miriam |e verfasserin |4 aut | |
700 | 1 | |a Riera-Bosch, Maria Teresa |e verfasserin |4 aut | |
700 | 1 | |a Rius, Neus |e verfasserin |4 aut | |
700 | 1 | |a Ruiz, Montserrat |e verfasserin |4 aut | |
700 | 1 | |a Sánchez, Almudena |e verfasserin |4 aut | |
700 | 1 | |a Valldepérez, Cinta |e verfasserin |4 aut | |
700 | 1 | |a Vilà, Mònica |e verfasserin |4 aut | |
700 | 1 | |a Pineda, Valentí |e verfasserin |4 aut | |
700 | 1 | |a Lazcano, Uxue |e verfasserin |4 aut | |
700 | 1 | |a Díaz, Yesika |e verfasserin |4 aut | |
700 | 1 | |a Reyes-Urueña, Juliana |e verfasserin |4 aut | |
700 | 1 | |a Soler-Palacín, Pere |e verfasserin |4 aut | |
700 | 0 | |a COVID-19 Pediatric Disease in Catalonia Research Group |e verfasserin |4 aut | |
700 | 1 | |a García-Lorenzo, Marc |e investigator |4 oth | |
700 | 1 | |a Braviz, Lorena |e investigator |4 oth | |
700 | 1 | |a Naranjo, Àngels |e investigator |4 oth | |
700 | 1 | |a Salvadó, Olga |e investigator |4 oth | |
700 | 1 | |a Burgaya, Silvia |e investigator |4 oth | |
700 | 1 | |a Aulet, Lidia |e investigator |4 oth | |
700 | 1 | |a Cantero, Javier |e investigator |4 oth | |
700 | 1 | |a Ruiz, Gloria |e investigator |4 oth | |
700 | 1 | |a Fenoy, Marina |e investigator |4 oth | |
700 | 1 | |a Martínez-Mejías, Abel |e investigator |4 oth | |
700 | 1 | |a González, Iris |e investigator |4 oth | |
700 | 1 | |a Foguet, Anton |e investigator |4 oth | |
700 | 1 | |a Bayona, Imma |e investigator |4 oth | |
700 | 1 | |a García, Guillermo |e investigator |4 oth | |
700 | 1 | |a Solé, Laia |e investigator |4 oth | |
700 | 1 | |a Calbet, Clara |e investigator |4 oth | |
700 | 1 | |a Carulla, Mireia |e investigator |4 oth | |
700 | 1 | |a Piquè, Neus |e investigator |4 oth | |
700 | 1 | |a Llobet, Pilar |e investigator |4 oth | |
700 | 1 | |a Pujol, Berta |e investigator |4 oth | |
700 | 1 | |a Díaz-Conradi, Álvaro |e investigator |4 oth | |
700 | 1 | |a Esteller, Maria |e investigator |4 oth | |
700 | 1 | |a Rosich, Blanca |e investigator |4 oth | |
700 | 1 | |a Gómez, Arantxa |e investigator |4 oth | |
700 | 1 | |a Ristol, Anna Mª |e investigator |4 oth | |
700 | 1 | |a Guarch, Borja |e investigator |4 oth | |
700 | 1 | |a Ripoll, Francesc |e investigator |4 oth | |
700 | 1 | |a Chiné, Maria |e investigator |4 oth | |
700 | 1 | |a Losana, Carlos |e investigator |4 oth | |
700 | 1 | |a Conti, Romina |e investigator |4 oth | |
700 | 1 | |a Zambudio, Isabel |e investigator |4 oth | |
700 | 1 | |a Escuer, Mercè |e investigator |4 oth | |
700 | 1 | |a Manuel Torres, Joan |e investigator |4 oth | |
700 | 1 | |a Perez-Porcuna, Tomas |e investigator |4 oth | |
700 | 1 | |a Mora, Emiliano |e investigator |4 oth | |
700 | 1 | |a García-Puig, Roger |e investigator |4 oth | |
700 | 1 | |a Prado, Silvia |e investigator |4 oth | |
700 | 1 | |a Gros, Daniel |e investigator |4 oth | |
700 | 1 | |a Giribet, Mercè |e investigator |4 oth | |
700 | 1 | |a Villalobos, Pili |e investigator |4 oth | |
700 | 1 | |a Canadell, Dolors |e investigator |4 oth | |
700 | 1 | |a Bruna, Xavier |e investigator |4 oth | |
700 | 1 | |a Martínez-Carbonell, Elisenda |e investigator |4 oth | |
700 | 1 | |a Bordas, Anna |e investigator |4 oth | |
700 | 1 | |a Sentis, Alexis |e investigator |4 oth | |
700 | 1 | |a Aceiton, Jordi |e investigator |4 oth | |
700 | 1 | |a Casabona, Jordi |e investigator |4 oth | |
700 | 1 | |a Herrero, Carlos |e investigator |4 oth | |
700 | 1 | |a Casas, Isabel |e investigator |4 oth | |
700 | 1 | |a Joaqui, Nathalia |e investigator |4 oth | |
700 | 1 | |a Laveglia, Vanessa |e investigator |4 oth | |
700 | 1 | |a Vilagrasa, Grisel |e investigator |4 oth | |
700 | 1 | |a Méndez, Maria |e investigator |4 oth | |
700 | 1 | |a Minguell, Laura |e investigator |4 oth | |
700 | 1 | |a Visa, Núria |e investigator |4 oth | |
700 | 1 | |a Paredes, Fernando |e investigator |4 oth | |
700 | 1 | |a Vidal-Moreso, Anna |e investigator |4 oth | |
700 | 1 | |a Díez, Rosario |e investigator |4 oth | |
700 | 1 | |a Moreira, Ana |e investigator |4 oth | |
700 | 1 | |a Berbel, Evelyn |e investigator |4 oth | |
700 | 1 | |a Schneider, Stephan |e investigator |4 oth | |
700 | 1 | |a Milà, Maria |e investigator |4 oth | |
700 | 1 | |a Maldonado, Ana |e investigator |4 oth | |
700 | 1 | |a Caubet, Imma |e investigator |4 oth | |
700 | 1 | |a Campins, Magda |e investigator |4 oth | |
700 | 1 | |a Esperalba, Juliana |e investigator |4 oth | |
700 | 1 | |a Anton, Andrés |e investigator |4 oth | |
700 | 1 | |a Gómez I Prat, Jordi |e investigator |4 oth | |
700 | 1 | |a Morales, Raisa |e investigator |4 oth | |
700 | 1 | |a Santos, José |e investigator |4 oth | |
700 | 1 | |a Gussinyé, Pilar |e investigator |4 oth | |
700 | 1 | |a Fenollosa, Teresa |e investigator |4 oth | |
700 | 1 | |a Moreno, Coral |e investigator |4 oth | |
700 | 1 | |a Azemar, Joan |e investigator |4 oth | |
700 | 1 | |a Duran, Xavier |e investigator |4 oth | |
700 | 1 | |a Terrer, Gemma |e investigator |4 oth | |
700 | 1 | |a Galdeano, Evaristo |e investigator |4 oth | |
700 | 1 | |a Plasencia, Raquel |e investigator |4 oth | |
700 | 1 | |a Oglesby, Rebecca |e investigator |4 oth | |
700 | 1 | |a Vives-Oñós, Isabel |e investigator |4 oth | |
700 | 1 | |a Sabaté, Silvia |e investigator |4 oth | |
700 | 1 | |a Fernandez, Vanessa |e investigator |4 oth | |
700 | 1 | |a Ago, Cintia |e investigator |4 oth | |
700 | 1 | |a Castan, Anna |e investigator |4 oth | |
700 | 1 | |a Fornaguera, Francesc |e investigator |4 oth | |
700 | 1 | |a Panadés, Dolors |e investigator |4 oth | |
700 | 1 | |a Mónaco, Ernesto |e investigator |4 oth | |
700 | 1 | |a Ricós, Gemma |e investigator |4 oth | |
700 | 1 | |a Catasús, Gina |e investigator |4 oth | |
700 | 1 | |a Mendoza, Maria |e investigator |4 oth | |
700 | 1 | |a Busquets, Lidia |e investigator |4 oth | |
700 | 1 | |a Macià, Esperança |e investigator |4 oth | |
700 | 1 | |a Segura, Sandra |e investigator |4 oth | |
700 | 1 | |a Martín, Ramona |e investigator |4 oth | |
700 | 1 | |a Sandra López, Verónica |e investigator |4 oth | |
773 | 0 | 8 | |i Enthalten in |t Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |d 1992 |g 73(2021), 6 vom: 15. Sept., Seite e1261-e1269 |w (DE-627)NLM012603007 |x 1537-6591 |7 nnns |
773 | 1 | 8 | |g volume:73 |g year:2021 |g number:6 |g day:15 |g month:09 |g pages:e1261-e1269 |
856 | 4 | 0 | |u http://dx.doi.org/10.1093/cid/ciab228 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 73 |j 2021 |e 6 |b 15 |c 09 |h e1261-e1269 |