Tracking SARS-CoV-2 lineage B.1.1.7 dissemination : insights from nationwide spike gene target failure (SGTF) and spike gene late detection (SGTL) data, Portugal, week 49 2020 to week 3 2021
We show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83-95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B.1.1.7 spread, besides the spike gene target failure (SGTF) proxy. SGTL/SGTF samples were associated with statistically significant higher viral loads, but not with substantial shift in age distribution compared to non-SGTF/SGTL cases.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 26(2021), 10 vom: 11. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Borges, Vítor [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 16.03.2021 Date Revised 31.03.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.2807/1560-7917.ES.2021.26.10.2100130 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM322637597 |
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| 245 | 1 | 0 | |a Tracking SARS-CoV-2 lineage B.1.1.7 dissemination |b insights from nationwide spike gene target failure (SGTF) and spike gene late detection (SGTL) data, Portugal, week 49 2020 to week 3 2021 |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 16.03.2021 | ||
| 500 | |a Date Revised 31.03.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83-95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B.1.1.7 spread, besides the spike gene target failure (SGTF) proxy. SGTL/SGTF samples were associated with statistically significant higher viral loads, but not with substantial shift in age distribution compared to non-SGTF/SGTL cases | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a B.1.1.7 lineage | |
| 650 | 4 | |a RT-PCR | |
| 650 | 4 | |a SARS-CoV-2 | |
| 650 | 4 | |a genome sequencing | |
| 650 | 4 | |a laboratory surveillance | |
| 650 | 4 | |a spike gene target failure (SGTF) | |
| 650 | 4 | |a spike gene target late detection (SGTL) | |
| 650 | 7 | |a Spike Glycoprotein, Coronavirus |2 NLM | |
| 650 | 7 | |a spike protein, SARS-CoV-2 |2 NLM | |
| 700 | 1 | |a Sousa, Carlos |e verfasserin |4 aut | |
| 700 | 1 | |a Menezes, Luís |e verfasserin |4 aut | |
| 700 | 1 | |a Gonçalves, António Maia |e verfasserin |4 aut | |
| 700 | 1 | |a Picão, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Almeida, José Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Vieita, Margarida |e verfasserin |4 aut | |
| 700 | 1 | |a Santos, Rafael |e verfasserin |4 aut | |
| 700 | 1 | |a Silva, Ana Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Costa, Mariana |e verfasserin |4 aut | |
| 700 | 1 | |a Carneiro, Luís |e verfasserin |4 aut | |
| 700 | 1 | |a Casaca, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Pinto-Leite, Pedro |e verfasserin |4 aut | |
| 700 | 1 | |a Peralta-Santos, André |e verfasserin |4 aut | |
| 700 | 1 | |a Isidro, Joana |e verfasserin |4 aut | |
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| 700 | 1 | |a Nunes, Baltazar |e verfasserin |4 aut | |
| 700 | 1 | |a Gomes, João P |e verfasserin |4 aut | |
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