Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers
We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23-11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09-10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:10 |
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| Enthalten in: |
Emerging microbes & infections - 10(2021), 1 vom: 04. Dez., Seite 493-496 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Martínez-Sanz, Javier [VerfasserIn] |
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| Links: |
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| Themen: |
ACE2 protein, human |
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| Anmerkungen: |
Date Completed 31.03.2021 Date Revised 28.04.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1080/22221751.2021.1902755 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a We aim to evaluate the role of single-nucleotide polymorphisms of the angiotensin-converting enzyme 2 in susceptibility to SARS-CoV-2 infection. We included 28 uninfected but highly exposed healthcare workers and 39 hospitalized patients with COVID-19. Thirty-five SNPs were rationally selected. Two variants were associated with increased risk of being susceptible to SARS-CoV-2: the minor A allele in the rs2106806 variant (OR 3.75 [95% CI 1.23-11.43]) and the minor T allele in the rs6629110 variant (OR 3.39 [95% CI 1.09-10.56]). Evaluating the role of genetic variants in susceptibility to SARS-CoV-2 infection could help identify more vulnerable individuals and suggest potential drug targets for COVID-19 patients | ||
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| 700 | 1 | |a Cruz, Raquel |e verfasserin |4 aut | |
| 700 | 1 | |a Vizcarra, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Conde, Matilde |e verfasserin |4 aut | |
| 700 | 1 | |a Ron, Raquel |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Herrera, Sabina |e verfasserin |4 aut | |
| 700 | 1 | |a Moreno, Santiago |e verfasserin |4 aut | |
| 700 | 1 | |a López-Huertas, María Rosa |e verfasserin |4 aut | |
| 700 | 1 | |a Serrano-Villar, Sergio |e verfasserin |4 aut | |
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