Physical activity and cardiac autonomic dysfunction in patients with chronic obstructive pulmonary disease : A cross-sectional analysis
Copyright © 2021 Elsevier Masson SAS. All rights reserved..
BACKGROUND: The cardiac autonomic function in patients with chronic obstructive pulmonary disease (COPD) has been poorly studied.
OBJECTIVES: We aimed to 1) describe the cardiac autonomic function assessed by heart rate recovery (HRR) and chronotropic response (CR) during a 6-min walk test (6MWT) and afterward and 2) estimate the association of physical activity with HRR and CR in COPD patients.
METHODS: This cross-sectional analysis included 320 patients with mild to very severe COPD. Physical activity (steps, time in any/moderate-to-vigorous/vigorous physical activity, intensity and sedentary time) was measured during 1 week by accelerometer. CR and HRR were measured during a 6MWT and 5min after, respectively, and their association with physical activity parameters was estimated by multivariable linear regression models.
RESULTS: Patients were 82% male and had a mean (SD) age 68 (8) years, post-bronchodilator FEV1 57 (18) % predicted, and walked a mean of 7716 (4139) steps/day. HRR was slow until 5min after the 6MWT; the mean (SD) HRR was 15 (10), 22 (11), 25 (12), 25 (12) and 27 (12) bpm after 1, 2, 3, 4 and 5min, respectively. The mean (SD) CR was 35% (16). After adjusting for relevant confounders, time in vigorous physical activity was significantly associated with a fast decrease in HRR (p=0.044) and an increase in CR (p=0.021). We found no independent association for other physical activity parameters.
CONCLUSION: A cardiac autonomic dysfunction is present in patients with mild to very severe COPD and is inversely related to the practice of vigorous physical activity. Trial registration ClinicalTrials.gov NCT01897298.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:65 |
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| Enthalten in: |
Annals of physical and rehabilitation medicine - 65(2022), 3 vom: 07. Mai, Seite 101501 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Delgado-Ortiz, Laura [VerfasserIn] |
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| Links: |
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| Themen: |
Autonomic nervous system |
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| Anmerkungen: |
Date Completed 17.05.2022 Date Revised 17.05.2022 published: Print-Electronic ClinicalTrials.gov: NCT01897298 Citation Status MEDLINE |
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| doi: |
10.1016/j.rehab.2021.101501 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM322199875 |
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| 100 | 1 | |a Delgado-Ortiz, Laura |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Physical activity and cardiac autonomic dysfunction in patients with chronic obstructive pulmonary disease |b A cross-sectional analysis |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 17.05.2022 | ||
| 500 | |a Date Revised 17.05.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT01897298 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a BACKGROUND: The cardiac autonomic function in patients with chronic obstructive pulmonary disease (COPD) has been poorly studied | ||
| 520 | |a OBJECTIVES: We aimed to 1) describe the cardiac autonomic function assessed by heart rate recovery (HRR) and chronotropic response (CR) during a 6-min walk test (6MWT) and afterward and 2) estimate the association of physical activity with HRR and CR in COPD patients | ||
| 520 | |a METHODS: This cross-sectional analysis included 320 patients with mild to very severe COPD. Physical activity (steps, time in any/moderate-to-vigorous/vigorous physical activity, intensity and sedentary time) was measured during 1 week by accelerometer. CR and HRR were measured during a 6MWT and 5min after, respectively, and their association with physical activity parameters was estimated by multivariable linear regression models | ||
| 520 | |a RESULTS: Patients were 82% male and had a mean (SD) age 68 (8) years, post-bronchodilator FEV1 57 (18) % predicted, and walked a mean of 7716 (4139) steps/day. HRR was slow until 5min after the 6MWT; the mean (SD) HRR was 15 (10), 22 (11), 25 (12), 25 (12) and 27 (12) bpm after 1, 2, 3, 4 and 5min, respectively. The mean (SD) CR was 35% (16). After adjusting for relevant confounders, time in vigorous physical activity was significantly associated with a fast decrease in HRR (p=0.044) and an increase in CR (p=0.021). We found no independent association for other physical activity parameters | ||
| 520 | |a CONCLUSION: A cardiac autonomic dysfunction is present in patients with mild to very severe COPD and is inversely related to the practice of vigorous physical activity. Trial registration ClinicalTrials.gov NCT01897298 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Autonomic nervous system | |
| 650 | 4 | |a Chronic obstructive | |
| 650 | 4 | |a Exercise | |
| 650 | 4 | |a Heart rate | |
| 650 | 4 | |a Pulmonary disease | |
| 700 | 1 | |a Arbillaga-Etxarri, Ane |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Chiaradía, Diego A |e verfasserin |4 aut | |
| 700 | 1 | |a Gimeno-Santos, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Barberan-Garcia, Anael |e verfasserin |4 aut | |
| 700 | 1 | |a Balcells, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a Rodríguez-Roisin, Robert |e verfasserin |4 aut | |
| 700 | 1 | |a Garcia-Aymerich, Judith |e verfasserin |4 aut | |
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