Proteoglycan Remodeling Is Accelerated in Females with Angina Pectoris and Diffuse Myocardial Fibrosis : the iPOWER Study
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature..
Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r2 = 0.38, p<0.001 and r2 = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Journal of cardiovascular translational research - 14(2021), 5 vom: 01. Okt., Seite 921-929 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mygind, Naja Dam [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 08.02.2022 Date Revised 08.02.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s12265-021-10106-y |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM322076099 |
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| 520 | |a Angina and no obstructive coronary artery disease (CAD) have an unfavorable prognosis, possibly due to diffuse myocardial fibrosis (DMF). In DMF the proteoglycans biglycan and versican are actively remodeled by matrix metalloproteinase. We investigated biglycan and versican in females with angina and possible DMF assessed by cardiac magnetic resonance (CMR). Seventy-one females with angina and no obstructive CAD were included. Asymptomatic females served as controls. Versican and biglycan were measured and CMR was performed measuring extracellular volume. Biglycan and versican levels were higher in symptomatic females compared with controls; 31.4 ng/mL vs. 16.4 ng/mL (p < 0.001) and 2.1 ng/mL vs. 1.8 ng/mL (p < 0.001) and moderately correlated to extracellular volume (r2 = 0.38, p<0.001 and r2 = 0.26, p = 0.015). Turnover of biglycan and versican was increased in angina females compared with controls and associated with extracellular volume, supporting a link between angina with no obstructive CAD and fibrotic remodeling | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Angina pectoris | |
| 650 | 4 | |a Cardiac magnetic resonance | |
| 650 | 4 | |a Coronary microvascular disease | |
| 650 | 4 | |a Diffuse myocardial fibrosis | |
| 650 | 4 | |a Extracellular matrix | |
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| 700 | 1 | |a Suhrs, Elena |e verfasserin |4 aut | |
| 700 | 1 | |a Bove, Kira Bang |e verfasserin |4 aut | |
| 700 | 1 | |a Genovese, Federica |e verfasserin |4 aut | |
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| 700 | 1 | |a Kastrup, Jens |e verfasserin |4 aut | |
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