Genetic polymorphisms of the serotonin transporter are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis
Copyright © 2021 Elsevier Inc. All rights reserved..
BACKGROUND: Mood disorders are the most frequent psychiatric disorders in patients with temporal lobe epilepsy caused by hippocampal sclerosis (TLE-HS). The pathophysiological mechanisms in common between TLE and mood disorders include abnormalities in the serotonergic pathway. We aimed to evaluate the association between serotonin transporter genetic polymorphisms - 5-HTTLPR and 5-HTTVNTR - and the presence of mood disorders in patients with TLE-HS.
METHODS: We evaluated 119 patients with TLE-HS, with and without psychiatric disorder; 146 patients diagnosed with major depressive disorder (MDD), and 113 healthy volunteers. Individuals were genotyped for the 5-HTTLPR and 5-HTTVNTR polymorphisms.
RESULTS: No difference was observed between the TLE-HS groups, healthy controls, and MDD without epilepsy. There was a correlation between the 12-allele of the 5-HTTVNTR and the family history of patients with epilepsy with TLE-HS (p = 0.013).
CONCLUSIONS: In this study conducted in two Brazilian centers, the serotonin transporter polymorphisms evaluated cannot be associated with depressive disorder in patients with TLE-HS. Still, they do have some influence over some clinical characteristics of epilepsy in TLE-HS. These data may not be reproduced in other populations with distinct ethnic characteristics.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:117 |
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| Enthalten in: |
Epilepsy & behavior : E&B - 117(2021) vom: 30. Apr., Seite 107854 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vincentiis, Silvia [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 20.04.2021 Date Revised 20.04.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.yebeh.2021.107854 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM321973437 |
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| 041 | |a eng | ||
| 100 | 1 | |a Vincentiis, Silvia |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Genetic polymorphisms of the serotonin transporter are not related with depression in temporal lobe epilepsy caused by hippocampal sclerosis |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 20.04.2021 | ||
| 500 | |a Date Revised 20.04.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Mood disorders are the most frequent psychiatric disorders in patients with temporal lobe epilepsy caused by hippocampal sclerosis (TLE-HS). The pathophysiological mechanisms in common between TLE and mood disorders include abnormalities in the serotonergic pathway. We aimed to evaluate the association between serotonin transporter genetic polymorphisms - 5-HTTLPR and 5-HTTVNTR - and the presence of mood disorders in patients with TLE-HS | ||
| 520 | |a METHODS: We evaluated 119 patients with TLE-HS, with and without psychiatric disorder; 146 patients diagnosed with major depressive disorder (MDD), and 113 healthy volunteers. Individuals were genotyped for the 5-HTTLPR and 5-HTTVNTR polymorphisms | ||
| 520 | |a RESULTS: No difference was observed between the TLE-HS groups, healthy controls, and MDD without epilepsy. There was a correlation between the 12-allele of the 5-HTTVNTR and the family history of patients with epilepsy with TLE-HS (p = 0.013) | ||
| 520 | |a CONCLUSIONS: In this study conducted in two Brazilian centers, the serotonin transporter polymorphisms evaluated cannot be associated with depressive disorder in patients with TLE-HS. Still, they do have some influence over some clinical characteristics of epilepsy in TLE-HS. These data may not be reproduced in other populations with distinct ethnic characteristics | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Amygdalo hippocampal epilepsy | |
| 650 | 4 | |a Depressive disorder, major | |
| 650 | 4 | |a Epilepsy, temporal lobe | |
| 650 | 4 | |a Genetic polymorphisms | |
| 650 | 4 | |a Serotonin transporter | |
| 650 | 7 | |a Serotonin Plasma Membrane Transport Proteins |2 NLM | |
| 700 | 1 | |a Alcantara, Juliana A |e verfasserin |4 aut | |
| 700 | 1 | |a Rzezak, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Kerr, Daniel S |e verfasserin |4 aut | |
| 700 | 1 | |a Gattaz, Wagner F |e verfasserin |4 aut | |
| 700 | 1 | |a van der Linden, Helio |c Jr |e verfasserin |4 aut | |
| 700 | 1 | |a Dos Santos, Bernardo |e verfasserin |4 aut | |
| 700 | 1 | |a Arruda, Francisco |e verfasserin |4 aut | |
| 700 | 1 | |a Chaim-Avancini, Tiffany |e verfasserin |4 aut | |
| 700 | 1 | |a Serpa, Mauricio H |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandes, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Moreno, Ricardo A |e verfasserin |4 aut | |
| 700 | 1 | |a Busatto, Geraldo F |e verfasserin |4 aut | |
| 700 | 1 | |a Alessi, Ruda |e verfasserin |4 aut | |
| 700 | 1 | |a Demarque, Renata |e verfasserin |4 aut | |
| 700 | 1 | |a Valente, Kette D |e verfasserin |4 aut | |
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