Impact of incident age-related macular degeneration and associated vision loss on vision-related quality of life
© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ..
BACKGROUND: We examined the associations between the 6-year incidence of age-related macular degeneration (AMD) and vision-related quality of life (VRQoL), and the contribution of presenting visual acuity (VA), in an Asian population.
METHODS: Fundus images from the Singapore Chinese Eye Study, a population-based cohort study (baseline: 2009-2011; follow-up: 2015-2017), were graded using a modified Wisconsin age-related maculopathy grading system. Incident AMD was defined as no baseline AMD in both eyes and early/late AMD in the worse eye at follow-up. Presenting VA was assessed using the logarithm of the minimum angle of resolution chart at 4 m under standard lighting conditions with habitual correction. Multiple linear regression models determined the associations between AMD incidence with changes in the Rasch-transformed scores of the Reading, Mobility and Emotional VRQoL domains of the 32-item Impact of Visual Impairment (IVI-32) questionnaire, adjusted for traditional confounders. The contribution of presenting VA to changes in VRQoL was also estimated.
RESULTS: Of the 2251 participants without AMD at baseline (mean age (SD): 57.7 (9) years, 51.4% women), 101 (4.5%) and 11 (0.5%) developed incident early and late AMD at follow-up, respectively. Incident late AMD was associated with significant 30.3%, 32.5% and 30.9% decrements in Reading, Mobility and Emotional IVI scores, respectively. The contribution of presenting VA ranged between 1.62% and 4.35% of the observed decrements. No significant associations were noted with incident early AMD.
CONCLUSION: Incident late AMD had a substantial impact on all aspects of VRQoL, with presenting VA contributing only minimally to this longitudinal relationship.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:106 |
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| Enthalten in: |
The British journal of ophthalmology - 106(2022), 8 vom: 01. Aug., Seite 1063-1068 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Man, Ryan Eyn Kidd [VerfasserIn] |
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| Anmerkungen: |
Date Completed 25.07.2022 Date Revised 04.08.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1136/bjophthalmol-2020-318269 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM321957326 |
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| 520 | |a © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a BACKGROUND: We examined the associations between the 6-year incidence of age-related macular degeneration (AMD) and vision-related quality of life (VRQoL), and the contribution of presenting visual acuity (VA), in an Asian population | ||
| 520 | |a METHODS: Fundus images from the Singapore Chinese Eye Study, a population-based cohort study (baseline: 2009-2011; follow-up: 2015-2017), were graded using a modified Wisconsin age-related maculopathy grading system. Incident AMD was defined as no baseline AMD in both eyes and early/late AMD in the worse eye at follow-up. Presenting VA was assessed using the logarithm of the minimum angle of resolution chart at 4 m under standard lighting conditions with habitual correction. Multiple linear regression models determined the associations between AMD incidence with changes in the Rasch-transformed scores of the Reading, Mobility and Emotional VRQoL domains of the 32-item Impact of Visual Impairment (IVI-32) questionnaire, adjusted for traditional confounders. The contribution of presenting VA to changes in VRQoL was also estimated | ||
| 520 | |a RESULTS: Of the 2251 participants without AMD at baseline (mean age (SD): 57.7 (9) years, 51.4% women), 101 (4.5%) and 11 (0.5%) developed incident early and late AMD at follow-up, respectively. Incident late AMD was associated with significant 30.3%, 32.5% and 30.9% decrements in Reading, Mobility and Emotional IVI scores, respectively. The contribution of presenting VA ranged between 1.62% and 4.35% of the observed decrements. No significant associations were noted with incident early AMD | ||
| 520 | |a CONCLUSION: Incident late AMD had a substantial impact on all aspects of VRQoL, with presenting VA contributing only minimally to this longitudinal relationship | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a vision | |
| 700 | 1 | |a Gan, Alfred Tau Liang |e verfasserin |4 aut | |
| 700 | 1 | |a Fenwick, Eva K |e verfasserin |4 aut | |
| 700 | 1 | |a Teo, Kelvin Yi Chong |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Anna C S |e verfasserin |4 aut | |
| 700 | 1 | |a Cheung, Gemmy Chui Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Teo, Zhen Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Kumari, Neelam |e verfasserin |4 aut | |
| 700 | 1 | |a Wong, Tien Yin |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Ching-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Lamoureux, Ecosse Luc |e verfasserin |4 aut | |
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