Oral and anal carriage of Neisseria meningitidis among sexually active HIV-infected men who have sex with men in Denmark 2014-15
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved..
INTRODUCTION: Outbreaks of invasive meningococcal disease (IMD) among men who have sex with men (MSM) caused by a hypervirulent, non-encapsulated Neisseria meningitidis (Nm) clone belonging to genogroup C have been described. We aimed to determine the oral and anal carriage rates and genogroups of Nm among MSM living with HIV.
METHODS: Sexually active MSM living with HIV were included. A questionnaire, an oral wash sample and an anal swab were collected at baseline and 12 months follow-up. Identification of Nm and genogrouping was performed using real-time polymerase chain reaction analysis.
RESULTS: Among 82 MSM, the Nm carriage rate was 31.7% (95% CI 21.9-42.9) at baseline. The oral carriage rate was 24.4% (95% CI 15.6-35.1) and the anal rate was 11.0% (95% CI 5.1-19.8). Non-groupable Nm were most prevalent followed by genogroup B and genogroup Y. Rates were similar at follow-up.
CONCLUSION: Strains of Nm were detected in both oral washes and anal samples in our study. Our results suggest that Nm may be transmitted sexually among MSM. Non-groupable Nm were predominant in our population and no genogroup C Nm were detected.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:105 |
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| Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 105(2021) vom: 15. Apr., Seite 337-344 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tinggaard, Michaela [VerfasserIn] |
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| Links: |
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| Themen: |
Carriage |
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| Anmerkungen: |
Date Completed 02.06.2021 Date Revised 02.06.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijid.2021.02.062 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM321694600 |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a INTRODUCTION: Outbreaks of invasive meningococcal disease (IMD) among men who have sex with men (MSM) caused by a hypervirulent, non-encapsulated Neisseria meningitidis (Nm) clone belonging to genogroup C have been described. We aimed to determine the oral and anal carriage rates and genogroups of Nm among MSM living with HIV | ||
| 520 | |a METHODS: Sexually active MSM living with HIV were included. A questionnaire, an oral wash sample and an anal swab were collected at baseline and 12 months follow-up. Identification of Nm and genogrouping was performed using real-time polymerase chain reaction analysis | ||
| 520 | |a RESULTS: Among 82 MSM, the Nm carriage rate was 31.7% (95% CI 21.9-42.9) at baseline. The oral carriage rate was 24.4% (95% CI 15.6-35.1) and the anal rate was 11.0% (95% CI 5.1-19.8). Non-groupable Nm were most prevalent followed by genogroup B and genogroup Y. Rates were similar at follow-up | ||
| 520 | |a CONCLUSION: Strains of Nm were detected in both oral washes and anal samples in our study. Our results suggest that Nm may be transmitted sexually among MSM. Non-groupable Nm were predominant in our population and no genogroup C Nm were detected | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Carriage | |
| 650 | 4 | |a HIV | |
| 650 | 4 | |a Men who have sex with men | |
| 650 | 4 | |a Meningococcal disease | |
| 650 | 4 | |a Neisseria meningitidis | |
| 700 | 1 | |a Slotved, Hans-Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Fuursted, Kurt |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenstierne, Maiken Worsøe |e verfasserin |4 aut | |
| 700 | 1 | |a Kronborg, Gitte |e verfasserin |4 aut | |
| 700 | 1 | |a Lebech, Anne-Mette |e verfasserin |4 aut | |
| 700 | 1 | |a Thorsteinsson, Kristina |e verfasserin |4 aut | |
| 700 | 1 | |a Katzenstein, Terese L |e verfasserin |4 aut | |
| 700 | 1 | |a Storgaard, Merete |e verfasserin |4 aut | |
| 700 | 1 | |a Holden, Inge Kristine |e verfasserin |4 aut | |
| 700 | 1 | |a Johansen, Isik Somuncu |e verfasserin |4 aut | |
| 700 | 1 | |a Benfield, Thomas |e verfasserin |4 aut | |
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