Palladium-Catalyzed Dehydrogenative Fluoroalkoxylation of Benzaldehydes
A direct and efficient palladium-catalyzed oxidative dehydrogenative fluoroalkoxylation of benzaldehydes is reported here for the first time. The method features mild reaction conditions, good tolerance of functional groups, and a broad substrate scope. The protocol employs the transient directing group strategy, thereby avoiding the additional installation and removal of directing groups, endowing the method with great advantages of atom and step economy. The approach should find broad applications in drug synthesis and discovery processes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
Organic letters - 23(2021), 5 vom: 05. März, Seite 1921-1927 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jin, Long [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 15.06.2021 Date Revised 15.06.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1021/acs.orglett.1c00365 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM321652851 |
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| 500 | |a Date Revised 15.06.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a A direct and efficient palladium-catalyzed oxidative dehydrogenative fluoroalkoxylation of benzaldehydes is reported here for the first time. The method features mild reaction conditions, good tolerance of functional groups, and a broad substrate scope. The protocol employs the transient directing group strategy, thereby avoiding the additional installation and removal of directing groups, endowing the method with great advantages of atom and step economy. The approach should find broad applications in drug synthesis and discovery processes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Zhang, Xing-Long |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Rui-Li |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Meng-Yue |e verfasserin |4 aut | |
| 700 | 1 | |a Gao, Ya-Ru |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Yong-Qiang |e verfasserin |4 aut | |
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