Do Corticosteroid Injections for the Treatment of Pain Influence the Efficacy of mRNA COVID-19 Vaccines?
© The Author(s) 2020/2021. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
MYTH: Corticosteroid injection for the treatment of pain and inflammation is known to decrease the efficacy of the messenger ribonucleic acid (mRNA) vaccines for coronavirus disease 2019 (COVID-19).
FACT: There is currently no direct evidence to suggest that a corticosteroid injection before or after the administration of an mRNA COVID-19 vaccine decreases the efficacy of the vaccine.However, based on the known timeline of hypothalamic-pituitary-adrenal (HPA) axis suppression following epidural and intraarticular corticosteroid injections, and the timeline of the reported peak efficacy of the Pfizer-BioNTech and Moderna vaccines, physicians should consider timing an elective corticosteroid injection such that it is administered no less than 2 weeks prior to a COVID-19 mRNA vaccine dose and no less than 1 week following a COVID-19 mRNA vaccine dose, whenever possible.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Pain medicine (Malden, Mass.) - 22(2021), 4 vom: 20. Apr., Seite 994-1000 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Haewon [VerfasserIn] |
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| Links: |
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| Themen: |
Adrenal Cortex Hormones |
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| Anmerkungen: |
Date Completed 26.04.2021 Date Revised 13.12.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/pm/pnab063 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM321641817 |
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| 500 | |a Date Revised 13.12.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2020/2021. Published by Oxford University Press on behalf of the American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a MYTH: Corticosteroid injection for the treatment of pain and inflammation is known to decrease the efficacy of the messenger ribonucleic acid (mRNA) vaccines for coronavirus disease 2019 (COVID-19) | ||
| 520 | |a FACT: There is currently no direct evidence to suggest that a corticosteroid injection before or after the administration of an mRNA COVID-19 vaccine decreases the efficacy of the vaccine.However, based on the known timeline of hypothalamic-pituitary-adrenal (HPA) axis suppression following epidural and intraarticular corticosteroid injections, and the timeline of the reported peak efficacy of the Pfizer-BioNTech and Moderna vaccines, physicians should consider timing an elective corticosteroid injection such that it is administered no less than 2 weeks prior to a COVID-19 mRNA vaccine dose and no less than 1 week following a COVID-19 mRNA vaccine dose, whenever possible | ||
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| 650 | 7 | |a Vaccines, Synthetic |2 NLM | |
| 700 | 1 | |a Punt, Jennifer A |e verfasserin |4 aut | |
| 700 | 1 | |a Miller, David C |e verfasserin |4 aut | |
| 700 | 1 | |a Nagpal, Ameet |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Clark C |e verfasserin |4 aut | |
| 700 | 1 | |a Sayeed, Yusef |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Jaymin |e verfasserin |4 aut | |
| 700 | 1 | |a Stojanovic, Milan P |e verfasserin |4 aut | |
| 700 | 1 | |a Popescu, Adrian |e verfasserin |4 aut | |
| 700 | 1 | |a McCormick, Zachary L |e verfasserin |4 aut | |
| 700 | 0 | |a Spine Intervention Society’s Patient Safety Committee |e verfasserin |4 aut | |
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