Amino acids and vitamins status during continuous renal replacement therapy : An ancillary prospective observational study of a randomised control trial
Copyright © 2021 Société française d'anesthésie et de réanimation (Sfar). Published by Elsevier Masson SAS. All rights reserved..
BACKGROUND: Continuous renal replacement therapy (CRRT) is associated with micronutrients loss. Current recommendations are to administer 1-1.5g/kg/day of proteins during CRRT. We aim to evaluate the net effect of CRRT on amino acids (AA), vitamins A and C (Vit A, Vit C) levels.
METHODS: This is a prospective observational study embedded within a randomised controlled trial comparing two CRRT doses in patients with septic shock. CRRT was provided in continuous veno-venous haemofiltration mode at a dose of either 35ml/kg/h or 70ml/kg/h. All patients received parenteral nutrition with standard trace elements and vitamins (protein intake 1g/kg/d). We measured serum levels of glutamine, valine and alanine as well as Vit A and Vit C upon randomisation, study day four and eight. In addition, we measured a larger panel of AA in a subset of 11 patients.
RESULTS: We included 30 patients (17 allocated to 70ml/kg/h and 13 to 35ml/kg/h CRRT). Before CRRT initiation, mean plasma levels of glutamine and valine, Vit A and Vit C were low. CRRT was not associated with any significant change in AA levels except for a decrease in cystein. It was associated with an increase in Vit A and a decrease in Vit C levels. CRRT dose had no impact on those nutrients blood levels.
CONCLUSIONS: Irrespective of dose, CRRT was associated with a decrease in cysteine and Vit C and an increase in Vit A with no significant change in other AA. Further studies should focus on lean mass wasting during CRRT.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Anaesthesia, critical care & pain medicine - 40(2021), 2 vom: 05. Apr., Seite 100813 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Schneider, Antoine G [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 29.09.2021 Date Revised 29.09.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.accpm.2021.100813 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM321476786 |
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| 100 | 1 | |a Schneider, Antoine G |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Amino acids and vitamins status during continuous renal replacement therapy |b An ancillary prospective observational study of a randomised control trial |
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| 500 | |a Date Revised 29.09.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Société française d'anesthésie et de réanimation (Sfar). Published by Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a BACKGROUND: Continuous renal replacement therapy (CRRT) is associated with micronutrients loss. Current recommendations are to administer 1-1.5g/kg/day of proteins during CRRT. We aim to evaluate the net effect of CRRT on amino acids (AA), vitamins A and C (Vit A, Vit C) levels | ||
| 520 | |a METHODS: This is a prospective observational study embedded within a randomised controlled trial comparing two CRRT doses in patients with septic shock. CRRT was provided in continuous veno-venous haemofiltration mode at a dose of either 35ml/kg/h or 70ml/kg/h. All patients received parenteral nutrition with standard trace elements and vitamins (protein intake 1g/kg/d). We measured serum levels of glutamine, valine and alanine as well as Vit A and Vit C upon randomisation, study day four and eight. In addition, we measured a larger panel of AA in a subset of 11 patients | ||
| 520 | |a RESULTS: We included 30 patients (17 allocated to 70ml/kg/h and 13 to 35ml/kg/h CRRT). Before CRRT initiation, mean plasma levels of glutamine and valine, Vit A and Vit C were low. CRRT was not associated with any significant change in AA levels except for a decrease in cystein. It was associated with an increase in Vit A and a decrease in Vit C levels. CRRT dose had no impact on those nutrients blood levels | ||
| 520 | |a CONCLUSIONS: Irrespective of dose, CRRT was associated with a decrease in cysteine and Vit C and an increase in Vit A with no significant change in other AA. Further studies should focus on lean mass wasting during CRRT | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Amino acids | |
| 650 | 4 | |a Continuous renal replacement therapy | |
| 650 | 4 | |a Critically ill | |
| 650 | 4 | |a Metabolism | |
| 650 | 4 | |a Nutrition | |
| 650 | 4 | |a Vitamin A and C | |
| 650 | 7 | |a Amino Acids |2 NLM | |
| 650 | 7 | |a Vitamins |2 NLM | |
| 700 | 1 | |a Picard, Walter |e verfasserin |4 aut | |
| 700 | 1 | |a Honoré, Patrick M |e verfasserin |4 aut | |
| 700 | 1 | |a Dewitte, Antoine |e verfasserin |4 aut | |
| 700 | 1 | |a Mesli, Samir |e verfasserin |4 aut | |
| 700 | 1 | |a Redonnet-Vernhet, Isabelle |e verfasserin |4 aut | |
| 700 | 1 | |a Fleureau, Catherine |e verfasserin |4 aut | |
| 700 | 1 | |a Ouattara, Alexandre |e verfasserin |4 aut | |
| 700 | 1 | |a Berger, Mette M |e verfasserin |4 aut | |
| 700 | 1 | |a Joannes-Boyau, Olivier |e verfasserin |4 aut | |
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