Elevated Circulating IL-10 Producing Breg, but Not Regulatory B Cell Levels, Restrain Antibody-Mediated Rejection After Kidney Transplantation
Copyright © 2021 Luo, Luo, Zhang, Wang, Zhang, Yang, Shang, Wang, Wang, Pang, Feng, Liu, Xie, Feng and Li..
Background: Antibody-mediated rejection (AMR) occupies a major position for chronic rejection after kidney transplantation. Regulatory B cell (Breg) has been reported to have an inhibitory immune function, which contributes to the resistance for AMR.
Methods: A nested case-control study for nine healthy donors, 25 stable (ST) patients, and 18 AMR patients was performed to determine the type of Breg in maintaining immune tolerance and preventing AMR.
Results: Compared to the ST group, circulating interleukin (IL)-10+ Bregs, but not Bregs, significantly decreased. The receiver operating characteristic (ROC) curve analysis revealed that rather than the circulating Bregs, decreased circulating IL-10+ Breg levels were positively associated with AMR. However, kidney B cell and IL-10 infiltration was significantly increased in the AMR group with high expression of C-X-C motif chemokine 13 (CXCL13). In addition, circulating IL-10+ Bregs, rather than Bregs, remained higher than those at pre-operation, during the 90-day post-operation in immune homeostasis.
Conclusion: The circulating IL-10+ Breg levels are more appropriate measures for assessing the resistance of AMR after kidney transplantation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Frontiers in immunology - 11(2020) vom: 12., Seite 627496 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Luo, Yongsheng [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 24.06.2021 Date Revised 24.06.2021 published: Electronic-eCollection Citation Status MEDLINE |
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| doi: |
10.3389/fimmu.2020.627496 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM321443608 |
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| 100 | 1 | |a Luo, Yongsheng |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Elevated Circulating IL-10 Producing Breg, but Not Regulatory B Cell Levels, Restrain Antibody-Mediated Rejection After Kidney Transplantation |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Revised 24.06.2021 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Luo, Luo, Zhang, Wang, Zhang, Yang, Shang, Wang, Wang, Pang, Feng, Liu, Xie, Feng and Li. | ||
| 520 | |a Background: Antibody-mediated rejection (AMR) occupies a major position for chronic rejection after kidney transplantation. Regulatory B cell (Breg) has been reported to have an inhibitory immune function, which contributes to the resistance for AMR | ||
| 520 | |a Methods: A nested case-control study for nine healthy donors, 25 stable (ST) patients, and 18 AMR patients was performed to determine the type of Breg in maintaining immune tolerance and preventing AMR | ||
| 520 | |a Results: Compared to the ST group, circulating interleukin (IL)-10+ Bregs, but not Bregs, significantly decreased. The receiver operating characteristic (ROC) curve analysis revealed that rather than the circulating Bregs, decreased circulating IL-10+ Breg levels were positively associated with AMR. However, kidney B cell and IL-10 infiltration was significantly increased in the AMR group with high expression of C-X-C motif chemokine 13 (CXCL13). In addition, circulating IL-10+ Bregs, rather than Bregs, remained higher than those at pre-operation, during the 90-day post-operation in immune homeostasis | ||
| 520 | |a Conclusion: The circulating IL-10+ Breg levels are more appropriate measures for assessing the resistance of AMR after kidney transplantation | ||
| 650 | 4 | |a Clinical Trial | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Breg phenotyping | |
| 650 | 4 | |a antibody-mediated rejection | |
| 650 | 4 | |a dynamic | |
| 650 | 4 | |a homeostasis | |
| 650 | 4 | |a kidney transplantation | |
| 650 | 7 | |a IL10 protein, human |2 NLM | |
| 650 | 7 | |a Isoantibodies |2 NLM | |
| 650 | 7 | |a Interleukin-10 |2 NLM | |
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| 700 | 1 | |a Luo, Feifei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Kuanxin |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Shilei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Haojie |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Xianlei |e verfasserin |4 aut | |
| 700 | 1 | |a Shang, Wenjun |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Junxiang |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zhigang |e verfasserin |4 aut | |
| 700 | 1 | |a Pang, Xinlu |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Yonghua |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Hongchang |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Guiwen |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jinfeng |e verfasserin |4 aut | |
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