Detection of knee synovitis using non-contrast-enhanced qDESS compared with contrast-enhanced MRI
BACKGROUND: To assess diagnostic accuracy of quantitative double-echo in steady-state (qDESS) MRI for detecting synovitis in knee osteoarthritis (OA).
METHODS: Patients with different degrees of radiographic knee OA were included prospectively. All underwent MRI with both qDESS and contrast-enhanced T1-weighted magnetic resonance imaging (CE-MRI). A linear combination of the two qDESS images can be used to create an image that displays contrast between synovium and the synovial fluid. Synovitis on both qDESS and CE-MRI was assessed semi-quantitatively, using a whole-knee synovitis sum score, indicating no/equivocal, mild, moderate, and severe synovitis. The correlation between sum scores of qDESS and CE-MRI (reference standard) was determined using Spearman's rank correlation coefficient and intraclass correlation coefficient for absolute agreement. Receiver operating characteristic analysis was performed to assess the diagnostic performance of qDESS for detecting different degrees of synovitis, with CE-MRI as reference standard.
RESULTS: In the 31 patients included, very strong correlation was found between synovitis sum scores on qDESS and CE-MRI (ρ = 0.96, p < 0.001), with high absolute agreement (0.84 (95%CI 0.14-0.95)). Mean sum score (SD) values on qDESS 5.16 (3.75) were lower than on CE-MRI 7.13 (4.66), indicating systematically underestimated synovitis severity on qDESS. For detecting mild synovitis or higher, high sensitivity and specificity were found for qDESS (1.00 (95%CI 0.80-1.00) and 0.909 (0.571-1.00), respectively). For detecting moderate synovitis or higher, sensitivity and specificity were good (0.727 (95%CI 0.393-0.927) and 1.00 (0.800-1.00), respectively).
CONCLUSION: qDESS MRI is able to, however with an underestimation, detect synovitis in patients with knee OA.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
|---|---|
| Enthalten in: |
Arthritis research & therapy - 23(2021), 1 vom: 13. Feb., Seite 55 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
de Vries, Bas A [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Humans |
|---|
| Anmerkungen: |
Date Completed 21.06.2021 Date Revised 21.06.2021 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1186/s13075-021-02436-8 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM321413881 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM321413881 | ||
| 003 | DE-627 | ||
| 005 | 20231225175745.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s13075-021-02436-8 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1071.xml |
| 035 | |a (DE-627)NLM321413881 | ||
| 035 | |a (NLM)33581741 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a de Vries, Bas A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Detection of knee synovitis using non-contrast-enhanced qDESS compared with contrast-enhanced MRI |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 21.06.2021 | ||
| 500 | |a Date Revised 21.06.2021 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: To assess diagnostic accuracy of quantitative double-echo in steady-state (qDESS) MRI for detecting synovitis in knee osteoarthritis (OA) | ||
| 520 | |a METHODS: Patients with different degrees of radiographic knee OA were included prospectively. All underwent MRI with both qDESS and contrast-enhanced T1-weighted magnetic resonance imaging (CE-MRI). A linear combination of the two qDESS images can be used to create an image that displays contrast between synovium and the synovial fluid. Synovitis on both qDESS and CE-MRI was assessed semi-quantitatively, using a whole-knee synovitis sum score, indicating no/equivocal, mild, moderate, and severe synovitis. The correlation between sum scores of qDESS and CE-MRI (reference standard) was determined using Spearman's rank correlation coefficient and intraclass correlation coefficient for absolute agreement. Receiver operating characteristic analysis was performed to assess the diagnostic performance of qDESS for detecting different degrees of synovitis, with CE-MRI as reference standard | ||
| 520 | |a RESULTS: In the 31 patients included, very strong correlation was found between synovitis sum scores on qDESS and CE-MRI (ρ = 0.96, p < 0.001), with high absolute agreement (0.84 (95%CI 0.14-0.95)). Mean sum score (SD) values on qDESS 5.16 (3.75) were lower than on CE-MRI 7.13 (4.66), indicating systematically underestimated synovitis severity on qDESS. For detecting mild synovitis or higher, high sensitivity and specificity were found for qDESS (1.00 (95%CI 0.80-1.00) and 0.909 (0.571-1.00), respectively). For detecting moderate synovitis or higher, sensitivity and specificity were good (0.727 (95%CI 0.393-0.927) and 1.00 (0.800-1.00), respectively) | ||
| 520 | |a CONCLUSION: qDESS MRI is able to, however with an underestimation, detect synovitis in patients with knee OA | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Knee | |
| 650 | 4 | |a Magnetic resonance imaging | |
| 650 | 4 | |a Osteoarthritis | |
| 650 | 4 | |a Synovitis | |
| 700 | 1 | |a Breda, Stephan J |e verfasserin |4 aut | |
| 700 | 1 | |a Sveinsson, Bragi |e verfasserin |4 aut | |
| 700 | 1 | |a McWalter, Emily J |e verfasserin |4 aut | |
| 700 | 1 | |a Meuffels, Duncan E |e verfasserin |4 aut | |
| 700 | 1 | |a Krestin, Gabriel P |e verfasserin |4 aut | |
| 700 | 1 | |a Hargreaves, Brian A |e verfasserin |4 aut | |
| 700 | 1 | |a Gold, Garry E |e verfasserin |4 aut | |
| 700 | 1 | |a Oei, Edwin H G |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Arthritis research & therapy |d 2003 |g 23(2021), 1 vom: 13. Feb., Seite 55 |w (DE-627)NLM124870457 |x 1478-6362 |7 nnns |
| 773 | 1 | 8 | |g volume:23 |g year:2021 |g number:1 |g day:13 |g month:02 |g pages:55 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1186/s13075-021-02436-8 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 23 |j 2021 |e 1 |b 13 |c 02 |h 55 | ||