Combination Therapy with Etilefrine and Pleurodesis for Refractory Congenital Chylothorax
Copyright © 2020 by S. Karger AG, Basel..
Etilefrine, a sympathomimetic agent, is reportedly effective against postoperative chylothorax. However, its effectiveness in treating congenital chylothorax was unknown. We report herein a case of refractory congenital chylothorax treated with etilefrine in a late preterm neonate with massive fetal chylous pleural effusion. The chylothorax was unresponsive to previous treatments, including dietary and pharmacological treatment and thoracic duct ligation. The pleural effusion decreased after intravenous etilefrine was begun on day of life (DOL) 84 and resolved after the addition of chemical pleurodesis with OK-432 on DOL 90. This combination therapy may be a viable treatment option for cases of congenital chylothorax that are unresponsive to other treatments.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
|---|---|
| Enthalten in: |
Biomedicine hub - 5(2020), 3 vom: 05. Sept., Seite 907-911 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Tomobe, Yutaro [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Revised 11.02.2021 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1159/000509903 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM321248201 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM321248201 | ||
| 003 | DE-627 | ||
| 005 | 20231225175412.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1159/000509903 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1070.xml |
| 035 | |a (DE-627)NLM321248201 | ||
| 035 | |a (NLM)33564667 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Tomobe, Yutaro |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Combination Therapy with Etilefrine and Pleurodesis for Refractory Congenital Chylothorax |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 11.02.2021 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Copyright © 2020 by S. Karger AG, Basel. | ||
| 520 | |a Etilefrine, a sympathomimetic agent, is reportedly effective against postoperative chylothorax. However, its effectiveness in treating congenital chylothorax was unknown. We report herein a case of refractory congenital chylothorax treated with etilefrine in a late preterm neonate with massive fetal chylous pleural effusion. The chylothorax was unresponsive to previous treatments, including dietary and pharmacological treatment and thoracic duct ligation. The pleural effusion decreased after intravenous etilefrine was begun on day of life (DOL) 84 and resolved after the addition of chemical pleurodesis with OK-432 on DOL 90. This combination therapy may be a viable treatment option for cases of congenital chylothorax that are unresponsive to other treatments | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Congenital chylothorax | |
| 650 | 4 | |a Etilefrine | |
| 650 | 4 | |a Pleurodesis | |
| 700 | 1 | |a Mizuguchi, Uiko |e verfasserin |4 aut | |
| 700 | 1 | |a Shimotakahara, Akihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Shimojima, Naoki |e verfasserin |4 aut | |
| 700 | 1 | |a Okazaki, Kaoru |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biomedicine hub |d 2016 |g 5(2020), 3 vom: 05. Sept., Seite 907-911 |w (DE-627)NLM266162207 |x 2296-6870 |7 nnns |
| 773 | 1 | 8 | |g volume:5 |g year:2020 |g number:3 |g day:05 |g month:09 |g pages:907-911 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1159/000509903 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 5 |j 2020 |e 3 |b 05 |c 09 |h 907-911 | ||