Successful steroid pulse therapy for COVID-19 associated respiratory failure initially mimicking bortezomib-induced lung injury
From December 2019, a 71-year-old male underwent three cycles of a combination therapy of pomalidomide, bortezomib, and dexamethasone for relapsed multiple myeloma and a very good partial response was achieved. In March 2020, he developed a fever of 38.9°C and computed tomography revealed bilateral ground-glass opacities. Antibiotic therapy was ineffective. Bronchoscopy was performed and bortezomib-induced lung injury was initially suspected. Due to respiratory exacerbation, high-dose steroid therapy was administered, which resulted in a dramatic improvement of the patient's respiratory failure. Thereafter, reverse transcription polymerase chain reaction performed on a preserved bronchial lavage sample tested positive, and thus his diagnosis was corrected to COVID-19 pneumonia. It is difficult to discriminate COVID-19 pneumonia from drug-induced lung disease, as both disorders can present similar ground-glass opacities on computed tomography. Therefore, with this presented case, we summarize our experience with steroid therapy for COVID-19 associated respiratory distress at our institution.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:62 |
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| Enthalten in: |
Rinsho ketsueki] The Japanese journal of clinical hematology - 62(2021), 1 vom: 15., Seite 30-34 |
| Sprache: |
Japanisch |
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| Beteiligte Personen: |
Fujii, Takayuki [VerfasserIn] |
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| Links: |
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| Themen: |
69G8BD63PP |
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| Anmerkungen: |
Date Completed 11.02.2021 Date Revised 11.02.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.11406/rinketsu.62.30 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM321119479 |
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| 520 | |a From December 2019, a 71-year-old male underwent three cycles of a combination therapy of pomalidomide, bortezomib, and dexamethasone for relapsed multiple myeloma and a very good partial response was achieved. In March 2020, he developed a fever of 38.9°C and computed tomography revealed bilateral ground-glass opacities. Antibiotic therapy was ineffective. Bronchoscopy was performed and bortezomib-induced lung injury was initially suspected. Due to respiratory exacerbation, high-dose steroid therapy was administered, which resulted in a dramatic improvement of the patient's respiratory failure. Thereafter, reverse transcription polymerase chain reaction performed on a preserved bronchial lavage sample tested positive, and thus his diagnosis was corrected to COVID-19 pneumonia. It is difficult to discriminate COVID-19 pneumonia from drug-induced lung disease, as both disorders can present similar ground-glass opacities on computed tomography. Therefore, with this presented case, we summarize our experience with steroid therapy for COVID-19 associated respiratory distress at our institution | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Drug-induced lung injury | |
| 650 | 4 | |a Multiple myeloma | |
| 650 | 4 | |a Steroid therapy | |
| 650 | 7 | |a Steroids |2 NLM | |
| 650 | 7 | |a Bortezomib |2 NLM | |
| 650 | 7 | |a 69G8BD63PP |2 NLM | |
| 700 | 1 | |a Saito, Hiroki |e verfasserin |4 aut | |
| 700 | 1 | |a Ide, Shiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ohara, Shin |e verfasserin |4 aut | |
| 700 | 1 | |a Uchida, Tomoyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Inoue, Morihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Hagihara, Masao |e verfasserin |4 aut | |
| 700 | 1 | |a Kushimoto, Kohei |e verfasserin |4 aut | |
| 700 | 1 | |a Nishiura, Miho |e verfasserin |4 aut | |
| 700 | 1 | |a Oashi, Ayano |e verfasserin |4 aut | |
| 700 | 1 | |a Ochi, Junichi |e verfasserin |4 aut | |
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