Individual exposure to urban air pollution and its correlation with placental angiogenic markers in the first trimester of pregnancy, in São Paulo, Brazil
Pollution of the atmosphere is known that may lead to adverse obstetric outcomes, including fetal growth restriction, gestational hypertension, and preeclampsia. Such disorders are correlated with imbalances in angiogenic factors, which may also be involved in the pathological mechanism as the pollutants impact placental and maternal physiology. In the first trimester of gestation, this study assessed the outcomes of personal maternal short period exposure to air pollution on soluble fms-like tyrosine kinase 1 (sFlt1) and placental growth factor (PLGF) of pregnant women blood concentrations. This was a cross-sectional study, held in the city of São Paulo, Brazil, and conducted with low-risk pregnant women, who carried personal passive nitrogen dioxide (NO2) and ozone (O3) monitors for about a few days preceding the ultrasound evaluation, and on this day, the venous blood sample was collected to measure the angiogenic factors sFlt1 and PLGF and their ratio (sFlt1/PLGF) by enzyme-linked immunosorbent assay (ELISA). By means of multiple regression models, the effect of the studied pollutants on the log-transformed concentrations of the angiogenic factors was evaluated. One hundred thirty-one patients were included. The log of the sFlt1/PLGF ratio increased with rising NO2 levels (p = 0.021 and beta = 0.206), and the log of the PLGF concentration showed a negative correlation with NO2 (p = 0.008 and beta = - 0.234). NO2, an indicator of the levels of primary air pollutants, presented significant positive correlation with an increased sFlt1/PLGF ratio and diminished PLGF levels, which may reflect an antiangiogenic state generated by air pollution exposure.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Environmental science and pollution research international - 28(2021), 22 vom: 05. Juni, Seite 28658-28665 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hettfleisch, Karen [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 03.06.2021 Date Revised 24.08.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11356-021-12353-7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM321049284 |
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| 100 | 1 | |a Hettfleisch, Karen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Individual exposure to urban air pollution and its correlation with placental angiogenic markers in the first trimester of pregnancy, in São Paulo, Brazil |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Pollution of the atmosphere is known that may lead to adverse obstetric outcomes, including fetal growth restriction, gestational hypertension, and preeclampsia. Such disorders are correlated with imbalances in angiogenic factors, which may also be involved in the pathological mechanism as the pollutants impact placental and maternal physiology. In the first trimester of gestation, this study assessed the outcomes of personal maternal short period exposure to air pollution on soluble fms-like tyrosine kinase 1 (sFlt1) and placental growth factor (PLGF) of pregnant women blood concentrations. This was a cross-sectional study, held in the city of São Paulo, Brazil, and conducted with low-risk pregnant women, who carried personal passive nitrogen dioxide (NO2) and ozone (O3) monitors for about a few days preceding the ultrasound evaluation, and on this day, the venous blood sample was collected to measure the angiogenic factors sFlt1 and PLGF and their ratio (sFlt1/PLGF) by enzyme-linked immunosorbent assay (ELISA). By means of multiple regression models, the effect of the studied pollutants on the log-transformed concentrations of the angiogenic factors was evaluated. One hundred thirty-one patients were included. The log of the sFlt1/PLGF ratio increased with rising NO2 levels (p = 0.021 and beta = 0.206), and the log of the PLGF concentration showed a negative correlation with NO2 (p = 0.008 and beta = - 0.234). NO2, an indicator of the levels of primary air pollutants, presented significant positive correlation with an increased sFlt1/PLGF ratio and diminished PLGF levels, which may reflect an antiangiogenic state generated by air pollution exposure | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Air pollution | |
| 650 | 4 | |a Angiogenic factors | |
| 650 | 4 | |a First trimester | |
| 650 | 4 | |a Placental growth factor (PLGF) | |
| 650 | 4 | |a Pregnancy | |
| 650 | 4 | |a Soluble fms-like tyrosine kinase 1 (sFlt1) | |
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| 650 | 7 | |a Placenta Growth Factor |2 NLM | |
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| 700 | 1 | |a Carvalho, Mariana Azevedo |e verfasserin |4 aut | |
| 700 | 1 | |a Hoshida, Mara Sandra |e verfasserin |4 aut | |
| 700 | 1 | |a Pastro, Luciana Duzolina Manfré |e verfasserin |4 aut | |
| 700 | 1 | |a Saldiva, Silvia Regina Dias Medici |e verfasserin |4 aut | |
| 700 | 1 | |a Vieira, Sandra Elisabete |e verfasserin |4 aut | |
| 700 | 1 | |a Francisco, Rossana Pulcineli Vieira |e verfasserin |4 aut | |
| 700 | 1 | |a Saldiva, Paulo Hilário Nascimento |e verfasserin |4 aut | |
| 700 | 1 | |a Bernardes, Lisandra Stein |e verfasserin |4 aut | |
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